Following the chlamydial exposure, a series of events occur in host belonging to innate and adaptive immune systems. The first line defense against infections is mucosal secretions contain various antimicrobial peptides. complement system that can be part triggered by elementary bodies Chlamydiae. Chlamydiae escape from infect epithelial cells. are protected phagolysosome fusion generating incl...

Bovine vaginal cytobrush specimens were analyzed for the presence of Chlamydia spp. by a high-sensitivity, high-specificity quantitative PCR. The 53% prevalence of low-level Chlamydia psittaci and C. pecorum genital infection detected in virgin heifers suggests predominantely extragenital transmission of Chlamydia in cattle and conforms to the high seroprevalence of anti-Chlamydia antibodies.

females abortion is one of the most important sequela of genital infection with chlamydia trachomatis, mycoplasma hominis and ureaplasma urealyticum.in this study frequency of chlamydia trachomatis, mycoplasma hominis and ureaplasma urealyticum was studied in 125 females with habitual abortion by direct and indirect immunofluorescence tests and culture method and compared with 250 normal popula...

OBJECTIVE To investigate the frequency and risk factors for incident and redetected Chlamydia trachomatis infection in sexually active, young, multi-ethnic women in the community. DESIGN Cohort study. SETTING 20 London universities and Further Education colleges. PARTICIPANTS 954 sexually experienced women, mean age 21.5 years (range 16-27), 26% from ethnic minorities, who were recruited ...

OBJECTIVES To identify the proportion of cases of non-gonococcal urethritis (NGU) in which Chlamydia trachomatis was detected in patients and their partners, using DNA amplification testing; and to relate the importance of age and symptoms to the presence of chlamydial infection and so clarify the aetiology and epidemiology of NGU, with a view to reducing the prevalence of chlamydial infection ...

Genital Chlamydia trachomatis infections in women typically are asymptomatic and do not cause permanent upper genital tract (UGT) damage. Consistent with this presentation, type 2 innate and TH2 adaptive immune responses associated with dampened inflammation and tissue repair are elicited in the UGT of Chlamydia-infected women. Primary C. trachomatis infection of mice also causes no genital pat...

Background: Chlamydia trachomatis (CT) is a common cause of sexually transmitted infections (STI) and a prevalent microorganism found in the vaginal discharge of sexually active women. The infection usually has no symptoms; although it may cause chronic complications such as pelvic inflammatory disease (PID), ectopic pregnancy, chronic pelvic pain, tubal infertility and cervical cancer. This st...

Chlamydia trachomatis infection is the most common cause of sexually transmitted disease, leading to female pelvic inflammatory disease and infertility. The disease process has been linked to cellular response to this bacterial pathogen. This obligate intracellular pathogen infects macrophages, fibroblast cells, and epithelial and endothelial cells. We show in this study that infection of cervi...

The obligate intracellular bacterium Chlamydia trachomatis is the most common cause of bacterial sexually transmitted disease in the United States and the leading cause of preventable blindness worldwide. Prior exposure to C. trachomatis has been shown to provide incomplete protection against subsequent infection. One possible explanation for the limited immunity afforded by prior C. trachomati...

BACKGROUND Chlamydia trachomatis (Ct) and Chlamydia pneumoniae (Cp) are medically significant infectious agents associated with various chronic human pathologies. Nevertheless, specific roles in disease progression or initiation are incompletely defined. Both pathogens infect established cell lines in vitro and polymerase chain reaction (PCR) has detected Chlamydia DNA in various clinical speci...