Recently, the attention of researchers has been drawn toward the synthesis of chitosan derivatives and their nanoparticles with enhanced antimicrobial activities. In this study, chitosan derivatives with different azides and alkyne groups were synthesized using click chemistry, and these were further transformed into nanoparticles by using the ionotropic gelation method. A series of chitosan de...

objective(s): nanoparticles (nps) are known for their specific accumulation in the inflamed tissues of the colon and thus allow a selective delivery to the site of inflammation with minimum adverse effects. the main objective of this work is to attain mesalamine loaded chitosan nanoparticles as a carrier for oral delivery. methods: in this study, mesalamine loaded chitosan nanoparticles were pr...

The study investigates the effect of aluminium oxide nanoparticles as an additive to Madhuca Indica (mahua) methyl ester blends on performance, emission analysis of a single-cylinder direct injection diesel engine operated at a constant speed at different operating conditions. The test fuels are indicated as B10A0.2, B10A0.4, B20A0.2, B20A0.4 and diesel respectively. The results indica...

In this study, an easy synthesized method for preparation of chitosan/iron oxide nanocomposite as a bio-sorbent has been applied. Analytical techniques such as Fourier transform infrared spectroscopy, X-ray diffraction; Field emission scanning electron microscopy and transmission electron microscopy were utilized to survey of morphological structure and the functional groups characterization. T...

OBJECTIVE To prepare hydroxyethyl chitosan nanoparticles loaded with anti-human death receptor 5 single-chain antibody, and study their characteristics, functions, and mechanisms of action. MATERIALS AND METHODS The anti-human death receptor 5 single-chain antibody was constructed and expressed. Protein-loaded hydroxyethyl chitosan nanoparticles were prepared, and their size, morphology, part...

BACKGROUND AND METHODS A new cyclosporin A-loaded, PEGylated chitosan-modified lipid-based nanoparticle was developed to improve upon the formulation of cyclosporin A. PEGylated chitosan, synthesized in three steps using mild reaction conditions, was used to modify the nanoparticles. Cyclosporin A-loaded, PEGylated chitosan-modified nanoparticles were prepared using an emulsification/solvent ev...

Fe3O4 nanoparticles were synthesized and functionalized with (3-aminopropyl) trimethoxysilane (APTMS) chitosan, forming Fe3O4-NH2 Fe3O4-NH2-chitosan nanoparticles. The by a co-precipitation method functionalization was performed in further stages. characterized X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), zeta potential, transmission electron microscopy (TEM). result...

alzheimer's disease (ad) is a progressive neurodegenerative disease characterized by memory and cognitive dysfunction due to neuronal cell loss in higher brain centers. senile plaques containing amyloid β (aβ) are associated with this disease as well as a reduction in cholinergic neuron numbers. tacrine is a reversible cholinesterase inhibitor in clinical use to treat moderate forms of ad. chit...

Silver nanoparticles have been used in various fields, and several synthesis processes have been developed. The stability and dispersion of the synthesized nanoparticles is vital. The present article describes a novel approach for one-step synthesis of silver nanoparticles-embedded chitosan particles. The proposed approach was applied to simultaneously obtain and stabilize silver nanoparticles ...

Recently, increasing attention has been paid to lecithin/chitosan nanoparticles as colloidal drug delivery system showing the great potential to improve the permeation of encapsulated drug across various biological barriers [1, 2]. However, the overall poor stability of colloidal nanoparticles in an aqueous medium is a significant drawback in their development perspective. Therefore, the aim of...