نتایج جستجو برای: chitin synthesis inhibitors

تعداد نتایج: 587472  

Journal: :Cancer prevention research 2010
Lee W Wattenberg Steven Patterson Jennifer D Antonides

A consistent observation in studies of carcinogenesis is that some glycans are expressed differently in cancer cells than in normal cells. A well-known example is the aberrant β1-6 N-acetyl-d-glucosamine branching associated with metastasis and poor prognosis in many cancers. This commentary proposes that, although not found in normal mammalian cells, a chitin (β-1,4-linked N-acetyl-d-glucosami...

خاکشور, محمد صادق, پازوکی, جمیله,

Background and purpose: Chitin is one of the main components of crustaceans’ exoskeleton. Chitosan is produced by deacetylation of chitin. Molecular weight and degree of deacetylation play important roles in biological activity of chitin, chitosan, and their derivatives. So far, various derivatives of chitin and chitosan are obtained. The purpose of this study was to prepare derivatives o...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1971
E Cabib V Farkas

Previous work with yeast has indicated that chitin is the specific component of the septum between mother and daughter cell. Experiments with synchronized cells show that chitin synthesis is initiated at a precise time in the cell cycle. Newly discovered features of the chitin synthetase system suggest how this specificity in location and timing can be achieved. The particulate chitin synthetas...

Journal: :Eukaryotic cell 2010
Claire A Walker Beatriz L Gómez Héctor M Mora-Montes Kevin S Mackenzie Carol A Munro Alistair J P Brown Neil A R Gow Christopher C Kibbler Frank C Odds

The fungal pathogen Candida albicans produces dark-pigmented melanin after 3 to 4 days of incubation in medium containing l-3,4-dihydroxyphenylalanine (l-DOPA) as a substrate. Expression profiling of C. albicans revealed very few genes significantly up- or downregulated by growth in l-DOPA. We were unable to determine a possible role for melanin in the virulence of C. albicans. However, we show...

Journal: :Insect biochemistry and molecular biology 2008
Yasuyuki Arakane Charles A Specht Karl J Kramer Subbaratnam Muthukrishnan Richard W Beeman

The synthesis of chitin, the beta-1,4-linked polymer of N-acetylglucosamine, is catalyzed by chitin synthase (CHS). Chitin is essential for the structural integrity of the exoskeletal cuticle and midgut peritrophic membrane (PM) of insects. To study the functions of the two chitin synthase genes, TcCHS-A and TcCHS-B, during embryonic and adult development in the red flour beetle, Tribolium cast...

2015
Arne Schwelm Johan Fogelqvist Andrea Knaust Sabine Jülke Tua Lilja German Bonilla-Rosso Magnus Karlsson Andrej Shevchenko Vignesh Dhandapani Su Ryun Choi Hong Gi Kim Ju Young Park Yong Pyo Lim Jutta Ludwig-Müller Christina Dixelius

Plasmodiophora brassicae causes clubroot, a major disease of Brassica oil and vegetable crops worldwide. P. brassicae is a Plasmodiophorid, obligate biotrophic protist in the eukaryotic kingdom of Rhizaria. Here we present the 25.5 Mb genome draft of P. brassicae, developmental stage-specific transcriptomes and a transcriptome of Spongospora subterranea, the Plasmodiophorid causing powdery scab...

2015
Maria Siglreitmeier Baohu Wu Tina Kollmann Martin Neubauer Gergely Nagy Dietmar Schwahn Vitaliy Pipich Damien Faivre Dirk Zahn Andreas Fery Helmut Cölfen

A fabrication method of a multifunctional hybrid material is achieved by using the insoluble organic nacre matrix of the Haliotis laevigata shell infiltrated with gelatin as a confined reaction environment. Inside this organic scaffold magnetite nanoparticles (MNPs) are synthesized. The amount of MNPs can be controlled through the synthesis protocol therefore mineral loadings starting from 15 w...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2016
Vassilis Douris Denise Steinbach Rafaela Panteleri Ioannis Livadaras John Anthony Pickett Thomas Van Leeuwen Ralf Nauen John Vontas

Despite the major role of chitin biosynthesis inhibitors such as benzoylureas (BPUs) in the control of pests in agricultural and public health for almost four decades, their molecular mode of action (MoA) has in most cases remained elusive. BPUs interfere with chitin biosynthesis and were thought to interact with sulfonylurea receptors that mediate chitin vesicle transport. Here, we uncover a m...

Journal: :Agricultural and Biological Chemistry 1980

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