A cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) technique has been developed for enantioseparation of vinpocetine using an inexpensive 2-hydroxypropyl-β-CD (HP-β-CD) as the chiral selector (CS). The best chiral separation was achieved using 40 mM HP-β-CD as the CS in 50 mM phosphate buffer (pH 7.0) consisting of 40 mM sodium dodecyl sulfate (SDS) at a separation tempera...

A sensitive and selective method has been developed for the determination of ritodrine diastereomers in human serum using high-performance liquid chromatography with a chiral stationary phase column and a fluorescence detector. No interfering peaks from endogenous substances were observed. The method showed good reproducibility and accuracy, and the standard curve was linear up to 100 ng/mL wit...

This review describes current analytical technology for the analysis of chiral constituents in essential oils and other natural volatiles, flavor and fragrance compounds, and covers some important results achieved by natural compound chemists, food chemists, perfumers, and molecular biologists. The technique of enantioselective gas chromatography (GC) is described and applied for assigning abso...

A chiral organogelator has been synthesized that can be racemized and self-assembled in apolar solvents whilst at higher concentrations organogels are formed. Field emission scanning and transmission electron microscopy revealed the formation of bundle fibrils that are able to gelate the solvent. ¹H NMR studies showed hydrogen-bond interactions between the peptide head groups of neighbouring or...

Chiral, or asymmetric catalysis is the most efficient approach to chiral molecules in the enantiomerically enriched form. Organocatalysis and organometallic catalysis are nowadays the methods of choice in this field. In the first case enantiomerically pure chiral organic molecules of different symmetry classes exhibit catalytic effect, in the second one chiral organic molecule acts as the ligan...

A simple, sensitive and selective method of high-performance liquid chromatography (HPLC) has been successfully developed for separation of bavachinin enantiomers in Fructus Psoraleae and rat plasma. The separation and detection conditions of HPLC were optimized. Chiral bavachinin were separated with the mobile phase of methanol and water (70:30, v/v) at a flow rate of 1.0 mL/min. The linear ra...

A convenient synthetic method for the marine antibiotic (-)-malyngolide and its stereoisomers was accomplished from a chiral alpha-alkoxyketone (4), which was readily available as a chiron. Chiral quaternary carbon synthons (5a) and (5b) as the key intermediates were constructed by the chelation controlled addition of Grignard reagent to 4. The diastereomeric mixture of 5a and 5b was readily tr...

Micellar electrokinetic chromatography (MEKC) and capillary electrochromatography (CEC) are two of the major capillary electrophoresis (CE) modes that have been interfaced to mass spectrometry (MS) for sensitive and selective analysis of chiral compounds. This research combines these two modes and expands their applications in chiral CE analysis. Chapter 1 is a review of amino acid based molecu...

Chiral pesticides with S atoms as asymmetric centers are gaining great importance in the search for new modes of action. As rest chiral pesticides, determination stereoisomers separately has become crucial environmental risks assessment these pesticides. Therefore, development suitable extraction and clean-up methods well efficient stereoselective analytical techniques samples is essential. Cur...

an important property of electromagnetic fields, which arises from the interaction between fields and chiral molecules, is called optical chirality. by enhancing this field property, while maintaining constant input power, we are able to increase absorption of circularly polarized light by chiral molecules of a certain handedness. this enhancement is achieved through the use of achiral plasmoni...