Prior to the past few years, development of new therapies for acute myeloid leukemia (AML) has been disappointingly slow. For several decades, standard therapy AML consisted intensive induction chemotherapy, and potentially a subsequent hematopoietic stem cell transplant. Unfortunately, older patients are less responsive to, frequently unfit tolerate, such chemotherapy. Given that majority elde...

Annotation. The article presents the results of an experimental study dynamics changes in main female sex hormones with serial use doxorubicin. experiments were performed on 45 adult white rats. levels antimullerian hormone, estradiol and follicle-stimulating hormone studied. In total, 4 courses chemotherapy interval 3 weeks. After each course chemotherapy, hormonal status animals was studied t...

chemotherapy medication errors may lead to potentially harmful consequences while most of them could be preventable. this study aims to determine the incidence and type of drug handling and administration errors among the nurses and to identify possible contributing factors. setting of the study was a teaching hospital affiliated to shahid beheshti university of medical sciences, tehran, iran. ...

background: emergence of drug resistance has brought major problems in chemotherapy. using nutrients in combination with chemotherapy could be beneficial for improvement of sensitivity of tumors to drug resistance. soybean-derived isoflavones have been suggested as chemopreventive agents for certain types of cancer, particularly breast cancer. in this study, the synergistic effects of soy isofl...

The potential for medication error is great with chemotherapy agents because of their high toxicity profile, small therapeutic index, and numerous dose-limiting adverse effects. The oncology team involved with chemotherapy treatment planning and administration assumes an active role in preventing such events by obtaining and maintaining competency in dose calculations, having knowledge of dose-...

Hepatocellular carcinoma (HCC) is highly resistant to chemotherapeutic drugs, which markedly reduces the effect of chemotherapy. Lin28 has been shown to contribute to tumor relapse after chemotherapy; however, the relationship between Lin28 and chemotherapy drug resistance is unknown. In the present study, we established a drug-resistant Hep3B cell line to investigate the association between Li...

Background: Despite modern developments in its management, still major concerns remain about drug resistance in chemotherapy. Natural adjuvants combined with chemotherapy might be the answer. We examined the anti-cancer, anti-proliferative and synergistic effects of Sambucus nigra extract with cisplatin chemotherapy (CDDP) on MCF-7 and MDA-MB-231 human cancer cell lines. Methods: MCF-7 and MDA...

aim : the aim of this study is to design multi-walled carbon nanotubes (mwcnts) loaded with paclitaxel (ptx) anti-cancer drug and investigate its anti-cancerous efficacy of human gastric cancer. the sidewall surfaces of pristine mwcnts are highly hydrophobic. a major goal in carbon nanotube chemistry has been functionalization for aqueous solubility, and exploiting nano-tubes as macromolecules ...

Cancer cell phenotypes evolve during a tumor's treatment. In some cases, tumor cells acquire cancer stem cell-like (CSL) traits such as resistance to chemotherapy and diminished differentiation; therefore, targeting these may be therapeutically beneficial. this study we show that in progressive estrogen receptor positive (ER+) metastatic breast tumors, resistant subclones emerge following have ...