PI3K (phosphoinositide 3-kinase) is a key regulator of cell growth, metabolism and survival. The frequent activation of the PI3K pathway in cancer has stimulated widespread interest in identifying potent and selective inhibitors of PI3K isoforms. The present paper highlights recent progress in identifying such molecules and the challenges that remain for efforts to pharmacologically target the ...

Aalto University, P.O. Box 11000, FI-00076 Aalto www.aalto.fi Author Mari Ijäs Name of the doctoral dissertation Chemically modified and nanostructured graphene Publisher School of Science Unit Department of Applied Physics Series Aalto University publication series DOCTORAL DISSERTATIONS 126/2013 Field of research Theoretical and Computational Physics Manuscript submitted 12 June 2013 Date of ...

Recently, with the goal to study multiplicity of chemically peculiar stars, we carried out a survey of 40 stars using diffraction limited near infrared (IR) imaging with NAOS-CONICA (NACO) at the VLT. Here, we announce the detection of 27 near IR companion candidates around 25 late B-type chemically peculiar stars exhibiting strong overabundances of the chemical elements Hg and Mn in their atmo...

Any stellar system with a star formation history (SFH) more extended than a massive star’s lifetime will be composite in metallicity. Our method of chemically consistent evolutionary synthesis tries to account for the increasing initial metallicity of successive generations of stars. Using various sets of input physics for a range of metallicities 10 ≤ Z ≤ 0.05 we keep track of the ISM enrichme...

The human population may be exposed to potentially leukemogenic agents, either in the form of drugs and food additives or as environmental contaminants and pollutants. However, in spite of the large number and diversity of these chemicals, only a few have been implicated as human leukemogens. One such agent is benzene, a known bone marrow depressant. A number of case reports have associated chr...

A two-dimensional crystal of molybdenum disulfide (MoS2) monolayer is a photoluminescent direct gap semiconductor in striking contrast to its bulk counterpart. Exfoliation of bulk MoS2 via Li intercalation is an attractive route to large-scale synthesis of monolayer crystals. However, this method results in loss of pristine semiconducting properties of MoS2 due to structural changes that occur ...

N M R emission and e n h a n c e d absorpt i on o f p roduc t s o f radical react ions ( C I D N P ) is e x p l a i n e d b y nuc lear spin d e p e n d e n t ad iabat i c transit ions be tween singlet a n d tr iplet states o f transient radical pairs. I n m a g n e t i c fields larger than a b o u t 1 k G o n l y S — To-transit ions c ont r ibute t o nuc lear polar izat ion. F r o m a k inet i ...

Compared to two-dimensional substrates, only a few methodologies exist for the spatially controlled decoration of three-dimensional objects, such as microparticles. Combining electrohydrodynamic co-jetting with synthetic polymer chemistry, we were able to create two- and three-patch microparticles displaying chemically orthogonal anchor groups on three distinct surface patches of the same parti...