five CQ-treated mice, and two showed no measurable Alzheimer ␤-Amyloid Plaques A␤ in the pellet fraction and no detectable A␤ pathology by immunocytochemistry. The authors then examined the effects of a higher dose (30 mg/kg/d) for 9 weeks in older 21-month-old mice (n ϭ 20) as compared to Transgenic mice developing ␤-amyloid (A␤) plaques sham-fed mice (n ϭ 19). This resulted in a 41% decrease ...

As Brittenham’ has reviewed in detail, the use of the oral iron chelator LI has been associated with significant clinical and animal toxicity. One of the more controversial issues surrounding the human use of LI has been the possible development of autoimmune phenomena as manifested by development of autoantibodies such as antinuclear antibodies (ANA). The Canadian group investigating LI did no...

Natural Cell Patches In article number 2212748, Longjiang Zhang and co-workers report a multifunctional nanoplatform cRGD-PEG-MNP (RpMP). RpMPs act like cell patches to suppress macrophage pyroptosis, thus potently ameliorating the development of atherosclerosis via targeting plaque neovascularization. Chelator-free Gd3+-RpMPs exhibit persistent T1-weighted contrast-enhanced efficiency resident...

The synthesis, copper(II) complexation and biotin conjugation of a bifunctional chelator incorporating a cross-bridged macrocycle are described.

The peroxidation of membrane phospholipids induced in vitro by ascorbic acid or by dialuric acid (hydroxybarbituric acid) does not occur in the absence of traces of metal ions. Peroxidation induced by adding iron salts to phospholipids can either be promoted or inhibited by the chelators EDTA, diethylenetriaminepenta-acetic acid and bathophenanthrolinesulphonate, depending on the ratio [chelato...