Information on the efficacy of pegylated interferon (PEG-IFN) treatment of chronic hepatitis B (CHB) patients and predictors of the response based on real-world data is limited. Consecutive 201 patients who underwent PEG-IFN treatment for CHB were reviewed. A virological response (VR) was defined as a serum HBV DNA of <2000 IU/mL, and a combined response (CR) was defined a VR accompanied by ser...

We report a case of complete heart block (CHB) in patient with rheumatoid arthritis (RA) because its atypical presentation, negative Anti CCP and one the uncommon causes CHB. It occurs mainly patients established erosive nodular RA. is usually sudden permanent. has several mechanisms, but most common cause infiltration or near AV node bundle His. If CHB develop best option treatment insertion p...

INTRODUCTION: Transforming growth factor-beta 1 (TGFβ1) is a potent suppressive cytokine that contributes to chronic hepatitis B (CHB) infection. Disparities in TGFβ1 production among individuals have been attributed to TGFβ1 genetic polymorphisms. We examined whether three putative polymorphisms in TGFβ1[-509 C/T (rs1800469), +869 C/T (rs1800470), and +11929 C/T (rs1800472)]are associated wit...

OBJECTIVE Neonatal lupus syndrome-congenital heart block (NLS-CHB) is an acquired autoimmune disease in which maternal autoantibodies are necessary but not sufficient for disease. Maternal myocardial cells have been found in the hearts of patients with NLS-CHB, suggesting that maternal microchimerism may also play a role. In this study we asked whether levels of microchimerism in the blood are ...

Hairpin pyrrole-imidazole polyamides (hPIPs) and their chlorambucil (Chb) conjugates (hPIP-Chbs) can alkylate DNA in a sequence-specific manner, have been studied as anticancer drugs. Here, we conjugated Chb to cyclic PIP (cPIP), which is known higher binding affinity than the corresponding hPIP, investigated alkylation properties of resulting cPIP-Chb using optimized capillary electrophoresis ...

single phase diode clamped multilevel inverter Department of.This paper presents a single phase multilevel inverter for using as a voltage harmonic source. First, a single phase multilevel inverter system is presented and.The structure of the multilevel inverter using cascaded-inverters with separated dc. single phase multilevel inverter 5 Single-phase configuration of an m-level cascaded inver...

With the advancements in semiconductor technology, high power medium voltage (MV) Drives are extensively used in numerous industrial applications. Challenging technical requirements of MV Drives is to control multilevel inverter (MLI) with less Total harmonic distortion (%THD) which satisfies IEEE standard 519-1992 harmonic guidelines and less switching losses. Among all modulation control stra...

Complete heart block (CHB) provides a useful substrate for study of bradycardia-dependent ventricular arrhythmias and cardiac function. Existing CHB animal models are limited by surgical recovery time and reliance on intrinsic escape rhythms. We describe a novel closed-chest rabbit model of CHB involving transcatheter radiofrequency (RF) atrioventricular (AV) node ablation and ventricular rate ...