نتایج جستجو برای: charge reversal substitutions
تعداد نتایج: 192530 فیلتر نتایج به سال:
In recent years, a growing number of protein folding studies have focused on the unfolded state, which is now recognized as playing a major role in the folding process. Some of these studies show that interactions occurring in the unfolded state can significantly affect the stability and kinetics of the protein folding reaction. In this study, we modeled the effect of electrostatic interactions...
A quantum simulator is an important device that may soon outperform current classical computations. A basic arithmetic operation, the complex conjugate, however, is considered to be impossible to be implemented in such a quantum system due to the linear character of quantum mechanics. Here, we present the experimental quantum simulation of such an unphysical operation beyond the regime of unita...
In order to study Hall effect in pure and CNT doped YBCO polycrystalline samples, we have measured longitudinal and transverse voltages at the different magnetic field (0-9T) in the vortex state. We found a sign reversal for pure sample near 3T and double sign reversal of the Hall coefficient for CNT doped sample near 3 and 5T. It can be deduced that CNT doping caused strong flux pinning and H...
It has previously been shown that, in the heterozygous state, mutations in the SOX9 gene cause campomelic dysplasia (CD) and the often associated autosomal XY sex reversal. In 12 CD patients, 10 novel mutations and one recurrent mutation were characterized in one SOX9 allele each, and in one case, no mutation was found. Four missense mutations are all located within the high mobility group (HMG...
The majority of known cytotoxic RNases are basic proteins which destroy intracellular RNA. Cationization of RNases is considered to be an effective strategy for strengthening their antitumor properties. We constructed a set of RNase Sa variants consisting of charge reversal mutants, charge neutralization mutants, and variants with positively charged cluster at the N-terminus. All constructs ret...
The stabilities of charge carriers, the transport properties, and the defect structures of the layered, quadruple perovskite La2Ba2Cu2Sn2O11 have been investigated by chemical substitutions, powder X-ray diffraction, and simultaneous high-temperature electrical conductivity and thermopower measurements. The in-plane copper-oxygen bond lengths, in cooperation with the copper-coordination environ...
We study edge states of noncentrosymmetric superconductors where spin-singlet d-wave pairing mixes with spin-triplet p (or f)-wave one by spin-orbit coupling. For d(xy)-wave pairing, the obtained Andreev bound state has an anomalous dispersion as compared to conventional helical edge modes. A unique topologically protected time-reversal invariant Majorana bound state appears at the edge. The ch...
Multidrug resistance protein 1 (MRP1) belongs to the ATP-binding cassette superfamily of transport proteins. In addition to drugs, MRP1 mediates the active transport of many conjugated and unconjugated organic anions. MRP1 consists of two membrane-spanning domains (MSD2 and MSD3) each followed by a nucleotide binding domain plus a third NH2-terminal MSD1. MSD2 contains transmembrane (TM) helice...
Numerical studies of hole migration along short DNA hairpins were performed with a particular emphasis on the variations of the rate and quantum yield of the charge separation process with the location of a single guanine:cytosine (G:C) base pair. Our calculations show that the hole arrival rate increases as the position of the guanine:cytosine base pair shifts from the beginning to the end of ...
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