Genomic selection, enabled by whole genome prediction (WGP) methods, is revolutionizing plant breeding. Existing WGP methods have been shown to deliver accurate predictions in the most common settings, such as prediction of across environment performance for traits with additive gene effects. However, prediction of traits with non-additive gene effects and prediction of genotype by environment ...

BACKGROUND Although both strength training (ST) and endurance training (ET) seem to be beneficial in type 2 diabetes mellitus (T2D), little is known about post-exercise glucose profiles. The objective of the study was to report changes in blood glucose (BG) values after a 4-month ET and ST programme now that a device for continuous glucose monitoring has become available. MATERIALS AND METHOD...

OBJECTIVE To compare the glycemic profiles of patients with type 1 diabetes treated with either an implantable insulin pump or pancreas or islet transplantation by the means of the continuous glucose monitoring system (CGMS; Minimed, Sylmar, CA). RESEARCH DESIGN AND METHODS The CGMS enabled recording of subcutaneous glucose concentrations (range 2.2-22 mmol/l) over 72 h (288 measurements per ...

GOAL models have been widely used in Computer Science to represent software requirements, business objectives, and design qualities. Existing goal modelling techniques, however, have shown limitations of expressiveness and/or tractability in coping with complex real-world problems. In this work, we exploit advances in automated reasoning technologies, notably Satisfiability and Optimization Mod...

The accuracy of a continuous glucose monitor (CGM) now supports its use by persons with diabetes and clinicians caring for them. This article reviews measures of CGM accuracy, factors contributing to accuracy, comparative accuracy assessment, clinical implications of CGM sensor accuracy, and recent clinical trials that have demonstrated the utility of CGMs.

Introduction: Alterations in the synthesis of cytokines have been demonstrated in gestational diabetes (GDM), but the association of cytokines with shortand long-term glycemic markers has not been defined clearly. In this study, the variations in the plasma levels of visfatin, TNF-α, IL-1β, IL-6, and IL-10 were investigated and theirassociations with glycemic markers -HbA1C, fructosamine, 1,5-a...

Oligodendrocyte lineage transcription factor 2 (OLIG2) plays a pivotal role in glioma development. Here we conducted a comprehensive study of the critical gene regulatory networks involving OLIG2. These include the networks responsible for OLIG2 expression, its translocation to nucleus, cell cycle, epigenetic regulation, and Rho-pathway interactions. We described positive feedback loops includi...

Detrended Fluctuation Analysis (DFA) measures the complexity of a glucose time series obtained by means of a Continuous Glucose Monitoring System (CGMS) and has proven to be a sensitive marker of glucoregulatory dysfunction. Furthermore, some authors have observed a crossover point in the DFA, signalling a change of dynamics, arguably dependent on the beta-insular function. We investigate wheth...

Continuous glucose monitors (CGMs) are prone to inaccuracy due to time lags, sensor drift, calibration errors, and measurement noise. The aim of this study is to derive the model of the error of the second generation Medtronic Paradigm Veo Enlite (ENL) sensor and compare it with the Dexcom SEVEN PLUS (7P), G4 PLATINUM (G4P), and advanced G4 for Artificial Pancreas studies (G4AP) systems. An enh...

Diabetic individuals need to tightly control their blood glucose concentration. Several methods have been developed for this purpose, such as the finger-prick or continuous glucose monitoring systems (CGMs). However, these methods present the disadvantage of being invasive. Moreover, CGMs have limited accuracy, notably to detect hypoglycemia. It is also known that physical exercise, and even da...