OBJECTIVE To evaluate whether a well developed collateral circulation predisposes to restenosis after percutaneous coronary intervention (PCI). DESIGN Prospective observational study. PATIENTS AND SETTING 58 patients undergoing elective single vessel PCI in a tertiary referral interventional cardiac unit in the UK. METHODS Collateral flow index (CFI) was calculated as (Pw-Pv)/(Pa-Pv), whe...

1 Instytut Informatyki, Uniwersytet Warszawski, Banacha 2, 02-097 Warszawa, Poland. chlebus@mimu., edu.pl 2 Laboratory for Computer Science, Massachusetts Institute of Technology, 545 Technology Square NE43-368, Cambridge, MA 02139, USA. robdep@theory. Ics. mit. edu Department of Computer Science and Engineering, University of Connecticut, 191 Auditorium Road, U-155, Storrs, CT 06269, USA. aas@...

4 Xavier Bonnet, Alain Fizesan, Catherine Louise Michel 5 6 7 1. CEBC-CNRS, 79360 Villers en Bois, France 8 9 Correspondance : Xavier Bonnet ; Tel +33 549 097 879 ; Fax +33 549 096 111 ; email 10 [email protected] 11 12 13 Submitted for consideration in Journal of Experimental Biology 14 15 16

The construct of expressed emotion (EE) is a highly reliable and valid predictor of poor clinical outcomes in patients with major psychopathology. Patients are at early risk for relapse if they live with family members who are classified as high in EE. Conventionally, EE is assessed with the Camberwell Family Interview (CFI), a semistructured interview that is conducted with the patient's key r...

The Self-Care of Heart Failure Index Version 6.2 (SCHFI v.6.2) is widely used, but its psychometric profile is still questioned. In a sample of 659 heart failure patients from Italy, we performed confirmatory factor analysis (CFA) to test the original construct of the SCHFI v.6.2 scales (Self-Care Maintenance, Self-Care Management, and Self-Care Confidence), with limited success. We then used e...

OBJECTIVE Metabolic syndrome (MetS) is a cluster of abdominal obesity, hyperglycemia, hypertension, and dyslipidemia, which increases the risk for type 2 diabetes and cardiovascular diseases (CVDs). Some argue that MetS is not a single disorder because the traditional MetS features do not represent one entity, and they would like to exclude features from MetS. Others would like to add additiona...

OBJECTIVES The goal of this clinical study was to assess the influence of hyperemic ipsilateral, collateral and contralateral vascular resistance changes on the coronary flow velocity reserve (CFVR) of the collateral-receiving (i.e. ipsilateral) artery, and to test the validity of a model describing the development of collateral steal. METHODS In 20 patients with one- to two-vessel coronary a...

In order to optimize surface CO2 fluxes at grid scales, a regional surface CO2 flux inversion system (Carbon Flux Inversion system and Community Multi-scale Air Quality, CFI-CMAQ) has been developed by applying the ensemble Kalman filter (EnKF) to constrain the CO2 concentrations and applying the ensemble Kalman smoother (EnKS) to optimize the surface CO2 fluxes. The smoothing operator is assoc...

BACKGROUND Coronary collaterals are essential to maintain myocardial function in chronic total coronary occlusions (TCOs). The aim of the present study was to assess the collateral circulation in TCOs before coronary angioplasty and to determine the recruitable collateral perfusion after recanalization by use of intracoronary Doppler flow velocimetry. METHODS AND RESULTS In 21 patients with T...

Loss of cell-cycle control is a hallmark of human cancer. Cell-cycle checkpoints are essential for maintaining genome integrity and balanced growth and division. They are specifically deregulated in cancer cells and contain regulators that represent potential therapeutic targets. Monopolar spindle 1 (Mps1; also known as TTK protein kinase) is a core component of the spindle assembly checkpoint ...