introduction: increasing incidence of cancers, particularly breast cancer (the third cause of death in iran), the role of information in decision making, policymaking and planning, and the need to assess the status of breast cancer in the country and the world necessitated a research to describe the advantages and disadvantages of the existing information on breast cancer patients. the present ...

Cervical cancer is always preceded by epithelial lesions which have larger and more densely spaced nuclei than normal tissue. Detecting and removing these lesions prevents the development of cervical cancer. A proposed method to detect precancerous lesion in vivo is to use the nuclear size and density information from fiber optic confocal images of the cervical epithelial tissue to classify the...

This study aimed to investigate the correlation between the expression of Ki67 and FasL and prognosis of cervical carcinoma and to explore the biological processes and signal pathways related to cervical carcinoma. Cervical carcinoma tissue specimens from 200 patients and normal tissue specimens adjacent to lesions from 30 cases were collected in this study. Ki67 and FasL proteins in these spec...

AIM Cyclins are a family of regulatory proteins that play a key role in controlling the cell cycle. Abnormalities of cell cycle regulators, including cyclins and cyclin dependent kinases, have been reported in various malignant tumors. This study was undertaken to quantitatively detect cyclin B1 and D1 in cervical cancer. METHODS A quantitative real-time reverse transcription polymerase chain...

Aurora kinase A (AurA) regulates genomic instability and tumorigenesis in multiple cancer types. Although some studies have reported that Aur A may predict cervical cancer outcomes, its precise function and molecular mechanism in cervical cancer pathogenesis remain unclear. In this study, by overexpression or silencing of Aur A in cervical cancer cell lines, we found that overexpression of Aur ...

Graphical abstract Abstract The phenomenal extracellular matrix (ECM) remodelling of the cervix that precedes myometrial contraction labour at term or preterm appears to share some common mechanisms with occurrence, growth, invasion and metastasis cervical carcinoma. Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases pivotal complex tissue modulation includes degradation, exchan...

Cervical cancer is the third most common cancer in women. In poor countries, it is the second cause of cancer death [1]. According to official report of World Health Organization, about 500,000 new cases of cervical cancer were recorded each year that more than half of them are leading to death. 80 percent of new cases are occurred in developing countries [2].

Despite considerable progress in understanding the function of peroxiredoxin (Prx) in cancer, its expression patterns have not been extensively studied in response to cervical carcinogenesis. We evaluated the expression of Prx isoforms in normal tissue, cervical intraepithelial neoplasia (CIN1, CIN2, and CIN3), and cervical cancer. We found strong pattern of increased Prx II and III immunostain...

Based on the accumulated data, FTIR spectroscopy seems to be a highly sensitive tool in cervical cancer diagnosis. We, therefore, employed this technique in a screening type of research here in Tehran. The purpose of this study was to look for the spectral pattern differences between normal and malignant cervix samples in Iranian women. Through formal and informal announcements, all gynecology ...