Introduction: Being able to measure cerebral perfusion and cerebral blood volume quantitatively is of great importance when it comes to diagnosing and treating various cerebrovascular diseases and other brain disorders. In a clinical setting, MR perfusion imaging is normally performed using dynamic susceptibility contrast imaging. When it comes to absolute quantification, this method has severa...

Acute occlusion of one common carotid artery in the anesthetized normocapnic rat results in a moderate cerebral blood flow (CBF) decrease in both cerebral hemispheres. No asymmetrical perfusion is observed when the overall flow in each hemisphere is considered. The increase in blood flow which normally occurs in hypercapnia is strongly impaired in the cerebral hemisphere on the occluded side re...

Background and Purpose: Cardiopulmonary resuscitation with external chest compression generates low perfusion pressures that may be inadequate for restoring cerebral metabolism and may worsen intracellular pH. We tested the hypothesis that cerebral reperfusion with a low perfusion pressure after arrest restores brain adenosine triphosphate (ATP) and pH to levels attained at the same perfusion p...

BACKGROUND AND PURPOSE Both cerebral hypoperfusion and vascular risk factors have been implicated in early aging of the brain and the development of neurodegenerative disease. However, the current knowledge of the importance of cardiovascular health on resting brain perfusion is limited. The aim of the present study was to elucidate the relation between brain perfusion variability and risk fact...

Soluble epoxide hydrolase (sEH), a key enzyme in the metabolism of vasodilatory epoxyeicosatrienoic acids (EETs), is sexually dimorphic, suppressed by estrogen, and contributes to underlying sex differences in cerebral blood flow and injury after cerebral ischemia. We tested the hypothesis that sEH inhibition or gene deletion in reproductively senescent (RS) female mice would increase cerebral ...

Regional cerebral blood flow (rCBF) and cerebral vasoreactivity were assessed in 28 consecutive patients who presented with retinal ischaemic symptoms, without clinical or cerebral CT evidence of cerebral ischaemia. rCBF was measured using xenon-133 inhalation and single photon emission computed tomography before and 20 minutes after the intravenous administration of 1 g acetazolamide. The find...

Hyperthermia reduces the capacity to withstand a simulated hemorrhagic challenge, but volume loading preserves this capacity. This study tested the hypotheses that acute volume expansion during hyperthermia increases cerebral perfusion and attenuates reductions in cerebral perfusion during a simulated hemorrhagic challenge induced by lower-body negative pressure (LBNP). Eight healthy young male...

The translational potential of pre-clinical stroke research depends on the accuracy of experimental modeling. Cerebral perfusion monitoring in animal models of acute ischemic stroke allows to confirm successful arterial occlusion and exclude subarachnoid hemorrhage. Cerebral perfusion monitoring can also be used to study intracranial collateral circulation, which is emerging as a powerful deter...

Significance: To explore brain architecture and pathology, a consistent reliable methodology to visualize the three-dimensional cerebral microvasculature is beneficial. Perfusion-based vascular labeling quick easily deliverable. However, quality of can vary with perfusion-based labels due aggregate formation, leakage, rapid photobleaching, incomplete perfusion. Aim: We describe simple, two-day ...