BACKGROUND AND PURPOSE N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP), an endogenously produced circulating peptide in humans and rodents, exerts anti-inflammatory and cardioprotective activities in various cardiovascular diseases. METHODS The present study evaluated the neuroprotective effect of AcSDKP alone and in combination with thrombolytic therapy in a rat model of embolic focal cerebra...

BACKGROUND AND PURPOSE This study uses T(2)* weighted imaging (T2*WI) to measure the temporal evolution of cerebral angiogenesis in rats subjected to embolic stroke up to 6 weeks after stroke onset with or without sildenafil treatment. Method- Male Wistar rats were subjected to embolic stroke and treated with saline (n=10) or with sildenafil (n=11), with treatment initiated at 24 hours and cont...

to minimize the risk of embolic events, several protection strategies have been introduced. we have evaluated the short-term outcome of patients who underwent carotid stenting with the routine use of cerebral protection devices. in our center, 36 successful carotid stenting procedures (of 38 attempted) were performed in 37 patients (23 men; age mean [sd] 667 years). cerebral protection involv...

Moyamoya disease (MMD) is an uncommon cerebrovascular disease that is characterized by progressive stenosis of the terminal portion of the internal carotid artery and its main branches. There have been many studies on the cerebral hemodynamics in patients with MMD, and based on their findings, current guidelines recommend revascularization surgery in patients with MMD with progressive ischemic ...

BACKGROUND AND PURPOSE Multiple acute brain infarctions in both cerebral hemispheres usually suggest an embolic mechanism, particularly one of aortic or cardiac origin. The purpose of this study was to clarify the etiologic mechanisms and topographic features of bihemispheric infarctions depicted on diffusion-weighted imaging (DWI). METHODS Among 411 consecutive patients with ischemic stroke ...

background: massive ischemic stroke causes significant mortality and morbidity in stroke patients. the main treatments for massive ischemic stroke are recombinant tissue plasminogen activator (rtpa), craniotomy, and endovascular interventions. due to destructive  effects  of   bradykinin  on  the  nervous system in ischemic stroke, it seems reasonable that using noscapine as a bradykinin antago...

Background and Purpose—We sought to determine risk factors for stroke and stroke type in persons with isolated systolic hypertension (ISH). Methods—We performed proportional hazards analyses of data from the Systolic Hypertension in the Elderly Program, a double-blind, randomized, placebo-controlled trial of 4736 persons aged $60 years with ISH (systolic blood pressure, 160 to 219 mm Hg; diasto...

BACKGROUND Due to the lack of specific diagnostic markers, the diagnosis of cancer-related stroke strongly depends on its phenotype. Distinct DWI lesion patterns with involvement of multiple vascular territories have been reported repeatedly in cancer-related stroke but have not been addressed in detail in a selected cohort of prospectively recruited cancer patients with emphasis on hypercoagul...