The article discusses the presentation of features cerebellar remodeling after traumatic brain injury (TBI) in highlands. experiment was carried out on 106 outbred male rats weighing 210-290 g compliance with rules laboratory practice. In high-altitude conditions, contrast to low-altitude significant changes occur cerebellum, namely, membrane potential cells, ectopia Purkinje pronounced molecul...

this study was conducted to evaluate the effect of soy milk on serum 17- β estradiol level and number of neurons in cerebral cortex and hippocampus as well as determination of the ratio of neurons in cortical and hippocampal regions in neonatal ovariectomized rats. thirty female rats (one day old) were divided into six groups of five. at day 7, ovariectomy surgery was performed in four groups a...

The neurons generated at the germinal rhombic lip undergo long distance migration along divergent pathways to settle in widely dispersed locations within the hindbrain, giving rise to cerebellar granule cells and precerebellar nuclei. Neurotrophin-3 (NT-3) signaling has been shown to be required for proper migration and survival of cerebellar granule cells. The molecular bases that govern NT-3 ...

Previous studies have indicated that neurons in the dorsomedial hypothalamic nucleus (DMN) receive feeding-related signals from the gastric vagal nerves, glycemia as well as leptin. On the other hand, it is intriguing that the cerebellum participates in regulating nonsomatic visceral activities including food intake via the direct cerebellohypothalamic projections. The present study was designe...

The neuropeptide somatostatin has been suggested to play an important role during neuronal development in addition to its established modulatory impact on neuroendocrine, motor and cognitive functions in adults. Although six somatostatin G protein-coupled receptors have been discovered, little is known about their distribution and function in the developing mammalian brain. In this study, we ha...

doi : 10.5214/ans.0972.7531.210311 Immunostaining pictures of rat cerebellar granule neurons treated with cerebrospinal fluid of multiple sclerosis patients. Apoptotic cell death occurred in cerebellar granule neurons but not astrocytes. 6 days culture of rat cerebellar granule neurons A) in control B,C,D) treated with cerebrospinal fluid of multiple sclerosis patients. Rhodamine-123 that fluor...

c-Aminobutyric acid (GABA)B receptors are known to enhance activation of Kir3 channels generating G-protein-dependent inward rectifier K-currents (GIRK). In some neurons, GABAB receptors either cause a tonic GIRK activation or generate a late K dependent inhibitory postsynaptic current component. However, other neurons express Kir2 channels, which generate a constitutive inward rectifier K-curr...

lithium (li), a glycogen synthase kinase-3β (gsk-3β) inhibitor, has used to attenuate thecannabinoid-induced dependence/withdrawal signs, but molecular mechanisms related to this areunclear. recent studies indicate the involvement of upstream extracellular signal kinase1/2 (erk1/2)and downstream gsk-3β pathways in the development of cannabinoid-induced dependence. thisis mediated through cannab...

gamma-Aminobutyric acid (GABA)(B) receptors are known to enhance activation of Kir3 channels generating G-protein-dependent inward rectifier K(+)-currents (GIRK). In some neurons, GABA(B) receptors either cause a tonic GIRK activation or generate a late K(+)-dependent inhibitory postsynaptic current component. However, other neurons express Kir2 channels, which generate a constitutive inward re...

The cerebellum receives its input from multiple precerebellar nuclei located in the brainstem and sends processed information to other brain structures via the deep cerebellar neurons. Guidance molecules that regulate the complex migrations of precerebellar neurons and the initial guidance of their leading processes have been identified. However, the molecules necessary for dorsal guidance of p...