work in the synthesis of podand molecules6), the present paper describes the preparation of certain podand-type trimers of cephalosporin antibiotics (Scheme 1 ). As the central block of the target trimers the tricarboxylic acid 3 was employed, which was obtained by the alkylation of phloroglucinol (1) with methyl bromoacetate and subsequent alkaline hydrolysis. The tert-butyl esters of 7-aminoc...

Vol. 23: Fundamentals in Cancer Chemotherapy. Anticancer Symposium held in Connection with the 10th International Congress of Chemotherapy, Zurich, September 1977. Ed.: F. M. SCHABEL, Jr. (Birmingham, Ala.). VIII +3 04 p., 62 fig., 1 cpl., 91 tab., 1978 ISBN 3-8055-2830-2 Vol. 24: Application of Cancer Chemotherapy. Anticancer Symposium held in Connection with the 10th International Congress of...

Enterococcus faecalis is a low-GC Gram-positive bacterium, a normal resident of the gastrointestinal (GI) tract, and an important hospital-acquired pathogen. An important risk factor for hospital-acquired enterococcal infections is prior therapy with broad-spectrum cephalosporins, antibiotics that impair cell wall biosynthesis by inhibiting peptidoglycan cross-linking. Enterococci are intrinsic...

BACKGROUND Severe bacterial keratitis (BK) typically requires intensive antimicrobial therapy. Empiric therapy is usually with a topical fluoroquinolone or fortified aminoglycoside-cephalosporin combination. Trials to date have not reached any consensus as to which antibiotic regimen most effectively treats BK. METHODS A systematic review and meta-analysis using Cochrane methodology was under...

The recommended treatment for gonorrhoea in the United Kingdom has, until recently, included the fluoroquinolone, ciprofloxacin, which consequently was used by most genitourinary medicine clinics. In 2002 national surveillance data showed that resistance to ciprofloxacin had risen to a prevalence of 9.8% (9% in 2003), indicating that the target of >95% efficacy in first line therapy was no long...