in this study, we investigated the effects of osmotic process with or without ultrasound on solid gain (sg) and water loss (wl) of cranberries. response surface methodology was used to model and determine the optimum processing conditions for wl and sg during osmotic dehydration of samples. sucrose (40-60%) and salt (0-8%) concentrations, temperature (30-50°c) and frequency of ultrasound (0-130...

Citric acid (CA) was evaluated in terms of its efficiency as a biodegradable chelating agent, in removing zinc (Zn) from heavily contaminated soil, using a soil washing process. To determine preliminary ranges of variables in the washing process, single factor experiments were carried out with different CA concentrations, pH levels and washing times. Optimization of batch washing conditions fol...

Objective: The objective of the present study was to develop and optimize Astragalin-loaded polymeric nanoparticles (AST-NPs) using a central composite factorial design (CCD). Methods: AST-NPs were prepared by dialysis method. CCD employed influence formulation factors, polymer concentration, aqueous organic phase ratio, process parameter stirring time on dependent physicochemical characteristi...

Co-fermentation of cheese whey (CW) and thermal-alkaline pre-treated Yerba Mate (Ilex paraguariensis) waste (YMW) was performed aiming to produce biohydrogen and/or short- medium-chain organic acids. Central Composite Designs (CCD) chosen as the experimental design for evaluating combinations three independent variables namely YMW concentration, pH inoculum concentration in hydrogen yield (H2Y;...

Meglumine antimoniate (MA) is a pentavalent antimony (SbV) drug recommended for the treatment of leishmaniasis. It known that trivalent (SbIII) present as residue in MA contributes to side effects. In this article, multivariate optimization was used synthesis order obtain with low levels SbIII. Four variables (source antimony, temperature, water volume and pH) were preliminarily evaluated by 24...

This study aimed to analyze and quantify the effect of different ratios vermicompost, phosphate rock, sulfur on P solubilization release by Pseudomonas fluorescens Ur21, identify optimal levels those variables for an efficient biofertilizer. Twenty experiments were defined surface response methodology based a central composite design (CCD), effects various quantities (encoded −1, 0, or +1) was ...

The present study deals with the production of cold active polygalacturonase (PGase) by submerged fermentation using Thalassospira frigidphilosprofundus, a novel species isolated from deep waters of Bay of Bengal. Nonlinear models were applied to optimize the medium components for enhanced production of PGase. Taguchi orthogonal array design was adopted to evaluate the factors influencing the y...

In this research, graphene oxide (GO) was functionalized by tannic acid to produce GO-TA and fabricate a novel functionalized graphene oxide/ polyacrylonitrile (PAN) nanofibrous as an adsorbent in order to remove two hazardous heavy metals from aqueous solutions. The results showed that the composite adsorbent can properly adsorb Pb2+ and Cd2+ metal cations, due to having the numerous potential...

A stability indicating QbD based gradient method was developed and validated with the concept of quality by design (QbD) and with help of design of experiments (DoE) tool for the simultaneous determination of related organic impurities of Ibuprofen and Paracetamol in a combination solid oral dosage form by reverse phase high performance liquid chromatography (RP-HPLC). The most important critic...