The Cre–LoxP system provides a widely used method for studying gene requirements in the mouse as main mammalian genetic model organism. To define molecular and cellular mechanisms that underlie cardiovascular development, function disease, various strains have been engineered allow Cre–LoxP-mediated targeting within specific cell types of system. Despite usefulness this system, evidence is accu...

Neurodegenerative diseases are complex multifactorial disorders characterised by the interplay of many dysregulated physiological processes. As an exemplar, Parkinson's disease (PD) involves multiple perturbed cellular functions, including mitochondrial dysfunction and autophagic dysregulation in preferentially-sensitive dopamine neurons, a selective pathophysiology recapitulated in vitro using...

free radicals are produced continuously in the cells as part of normal cellular function, however excess production might play a role in pathophysiology of many disease conditions, including cancer, alzheimer's disease, atherosclerosis and some of the drug-induced toxicity. many basic research studies and observational epidemiologic studies in human suggest that antioxidants can prevent oxidati...