An increasing body of research indicates that stroma surrounding cancer cells plays an important role in the development and subsequent behavior of the tumor. Studies using a wide range of techniques, including stromal cell isolation, modification of stromal-specific gene expression, and recreation of specific microenvironment conditions in culture, have demonstrated that stroma can promote can...

Targeted protein upregulation by modulating the interaction between a target and its E3 ligase is strategy opposite to targeted degradation (PROTAC). In their Research Article (e202300978), Dong-Sup Lee, Seung Bum Park enhanced cellular STING levels inhibiting STING-TRIM29 interaction, which activates innate immune responses in tumor microenvironment potentiates immune-oncology treatment changi...

a four year long research programme divided into four phases has been designed for the first time to assess the combined noise-air quality and combined exposure to noise-air pollution at the curbside open-air microenvironment of kolkata city, india. the results and the findings of the different phases of study had already been published. the objective of the review work is to fuse the findings ...

Inflammation impacts human hematopoiesis across physiologic and pathologic conditions, as signals derived from the bone marrow microenvironment, such pro-inflammatory cytokines chemokines, have been shown to alter hematopoietic stem cell (HSCs) homeostasis. Dysregulated inflammation can skew HSC fate-related decisions, leading aberrant potentially contributing pathogenesis of hematological diso...

Neural stem cells reside in a specialized vascular microenvironment that is termed “neural stem cell niche”, Brain vessels are the most important element in the NSC niche and paly an important role in balancing NSC’s maintenance and differentiation in order to maintain tissue homeostasis. In this study, we developed reconstituted 3D in vitro neural stem cell-vascular niche that consists of extr...

Applied forces and the biophysical nature of the cellular microenvironment play a central role in determining cellular behavior. Specifically, forces due to cell contraction are transmitted into structural ECM proteins and these forces are presumed to activate integrin "switches." The mechanism of such switches is thought to be the partial unfolding of integrin-binding domains within fibronecti...

A four year long research programme divided into four phases has been designed for the first time to assess the combined Noise-Air quality and combined exposure to Noise-Air pollution at the curbside open-air microenvironment of Kolkata city, India. The results and the findings of the different phases of study had already been published. The objective of the review work is to fuse the findings ...

Galvanotaxis is a complex process that represents the collective outcome of various contributing mechanisms, including asymmetric ion influxes, preferential activation of voltage-gated channels, and electrophoretic redistribution of membrane components. While a large number of studies have focused on various up- and downstream signaling pathways, little is known about how the surrounding microe...

Tissue engineering aims at repairing and restoring lost tissue structure and functions caused by disease processes or traumatic events (Langer and Vacanti 1993). Driven by clinical demands, extensive research efforts have been dedicated toward regenerating a broad range of tissues, from the skin, cartilage, bone, and blood vessels to more complex organ-level systems such as the bladder. Most ti...