In recent years, L-carnitine has been used increasingly as a supplement in livestock animals. The present review gives an overview of the effects of dietary L-carnitine supplementation on the reproductive performance of sows. Results concerning the effect of L-carnitine supplementation during pregnancy on litter sizes are controversial. There are some studies reporting an increased number of pi...

this experiment was conducted to investigate the effects of different levels of l-carnitine on productive performance, egg quality and blood parameters in laying hens. forty-eight hy-line w-36 egg layers were weighed at 90 weeks of age and randomly allocated into 16 cages (three hens per cage). four dietary treatments were prepared by supplementing l-carnitine (0, 50, 100 and 150 mg/kg of diet)...

11 children with either cystinosis or Lowe's syndrome had a reduced content of plasma and muscle carnitine due to renal Fanconi syndrome. After treatment with oral L-carnitine, 100 mg/kg per d divided every 6 h, plasma carnitine concentrations became normal in all subjects within 2 d. Initial plasma free fatty acid concentrations, inversely related to free carnitine concentrations, were reduced...

background: the present study was conducted to investigate the possible effects of l-carnitine and glutamine and their synergistic effects on male soccer athletes. methods: 28 male soccer players (21.1±0.7 y) were enrolled in a randomized pre and post intervention, double-blind design. before the intervention, their performances were assessed by bruce protocol, and their body composition was me...

Four experiments were conducted to evaluate the effects of supplementing graded levels (0 to 100 ppm) of L-carnitine to the diet of weanling pigs on growth performance during a 34- to 38-d experimental period. A fifth experiment was conducted to determine the effects of addition of L-carnitine to diets with or without added soybean oil (SBO) on growth performance. In Exp. 1, 128 pigs (initial B...

Systemic primary carnitine deficiency (CDSP) is a rare autosomal recessive disorder that presents episodic periods of hypoketotic hypoglycemia. The main symptoms of CDSP are skeletal and cardiac myopathy. CDSP is caused by a defect in plasma membrane uptake of carnitine, ultimately caused by the SLC22A5 gene. We report the case of a Korean patient with CDSP. He had an abnormal free carnitine le...

l-Carnitine was recently found to downregulate the ubiquitin proteasome pathway (UPP) and increase insulin-like growth factor 1 concentrations in animal models. However, the effect of l-carnitine administration on disuse muscle atrophy induced by hindlimb suspension has not yet been studied. Thus, we hypothesized that l-carnitine may have a protective effect on muscle atrophy induced by hindlim...

BACKGROUND L-Carnitine has been demonstrated to ameliorate cachectic symptoms. In the present study, we sought to investigate the role of the peroxisome proliferator-activated receptor-γ (PPAR-γ) signaling pathway in the ameliorative effects of L-carnitine on cancer cachexia in a colon-26 tumor-bearing mouse model. METHODS The cachectic mice received L-carnitine (p.o.) or etomoxir (i.p.), or ...

This study aimed to determine the serum levels of free L-carnitine, acetyl-L-carnitine and 34 acyl-L-carnitine in healthy subjects and in patients with or at risk of Alzheimer's disease. Twenty-nine patients with probable Alzheimer's disease, 18 with mild cognitive impairment of the amnestic type, 24 with subjective memory complaint and 46 healthy subjects were enrolled in the study, and the le...

BACKGROUND Depression is highly prevalent in uremic patients undergoing hemodialysis (HD). We previously found that low free-carnitine levels are associated with depression severity in male patients undergoing HD. However, whether L-carnitine supplementation improves the depression state in male patients undergoing HD remains unclear. METHODS Sixteen male patients undergoing HD were orally ad...