the use of animal models in modeling of human genetic disease has many advantages. in some cases, however, this method may not be applicable due to some limitations, such as differences in tissue composition, anatomy and physiology of humans and animals. isogenic human disease models are a population of cells that are selected or engineered to model a specific genetic disease, in vitro. they ar...

objective: piwil2, a member of ago/piwi gene family containing piwi and paz domains, has been shown to be ectopically expressed in different cancer cells, especially its remarkable expression in cancer stem cells (cscs), and is also known to be essential for germ line stem cell self-renewal in various organisms. the hypothesis that csc may hold the key to the central problem of clinical oncolog...

the purpose of this reaserch is to measure the phase equilibrium data of the ternary system (water + phosphoric acid + 1-nonanol) at different temperatures. experimental solubility curves and tie-line points for the system were obtained at t = 298.2, 308.2 and 318.2 k and ambient pressure. the binodal curve data were detected by the cloud point method. the mass fractions of each layer were achi...

background: autophagy suppression recently has been known to have a remarkable effect for cellular adjustment and viability in the final stages of cancer. on the other hand, autophagy has the potential effect in preventing many viruses from replication. beclin1 is the most substantial constituent in autophagy apparatus regulation. this study was intended to investigate the beclin1 sirna knockdo...

    Drug resistance enables cancer cells to break away from cytotoxic effect of anticancer drugs. Identification of resistant phenotype is very important because it can lead to effective treatment plan. There is an interest in developing classifying models of resistance phenotype based on the multivariate data. We have investigated a vibrational spectroscopic approach in order to characterize a...

PSA is a 33-KDa serine protease that is produced predominantly by prostate epithelium. However, it has been shown that about 30-40% of female breast tumors produce PSA and its production is associated with the presence of estrogen and progesterone receptors. We have now developed a new tissue culture system to study PSA production in breast cancer and its association with prognostic factors...

Objective(s): Exosomes are endogenous nanovesicles act as intercellular communication tools which have been considered to utilize as drug delivery systems. As transporting therapeutic molecules into brain has obstacles, preparing exosomes which have the potential to pass through its barriers is great challenge. Methods: Exosomes isolated from cell culture media of U87 glioblastoma ...