Mayaro virus (MAYV) is an emergent sylvatic alphavirus in South America, related to sporadic outbreaks of a chikungunya-like human febrile illness accompanied by severe arthralgia. Despite its high potential for urban emergence, MAYV is still an obscure virus with scarce information about its infection cycle, including the corresponding early events. Even for prototypical alphaviruses, the cell...

Delivery of cell-associated antigen represents an important strategy for vaccination. While many experimental models have been developed in order to define the critical parameters for efficient cross-priming, few have utilized quantitative methods that permit the study of the endogenous repertoire. Comparing different strategies of immunization, we report that local delivery of cell-associated ...

OBJECTIVE Adenosine, which has been used for a myocardial perfusion scan, shows rapid clearance from blood because of its short half-life of <10 seconds. This simulation study evaluates influences of modes of radionuclide injection on ventricular adenosine concentration when one intravenous injection line is used. METHODS Assuming that radionuclide injection is a unit impulse, time-activity c...

Abstract Unconventional T cells, which recognize monomorphic MHC Ib molecules, such as Qa1, Qa2, M3, CD1, and MR1 have been implicated in the primary response to Mycobacterium tuberculosis(Mtb) infection. However, whether these cells play a role molecules participate memory against Mtbinfection remains unknown. To determine optimal immunization strategy, we vaccinated mice that lack Ia (K b−/−D...

Erionite and crocidolite fibers were tested for carcinogenicity by intrapleural and intraperitoneal injection (una tantum) in 40 Sprague-Dawley rats per route for each fiber type. Pleural mesotheliomas were found in nine of ten animals that died within a year after intrapleural injection with erionite fibers. No pleural tumors were found among the animals treated at the same time and in the sam...

The optimal route for clinical delivery of oncolytic viruses is thought to be systemic intravenous injection; however, the immune system is armed with several highly efficient mechanisms to remove pathogens from the circulatory system. To overcome the challenges faced in trying to delivery oncolytic viruses specifically to tumors via the bloodstream, carrier cells have been investigated to dete...

Purpose: To investigate the influence of a combination Xuebijing and thymosin α1 on acute septic bronchopneumonia (ASB) patients, effect treatment inflammation.&#x0D; Methods: Eighty-one (81) ASB patients admitted to Tianjin Medical University General Hospital, China from January 2015 July 2019 were enrolled in study. The assigned control group (n = 41) study 40). treated with injection, i.v., ...

in this study, a crude leishmanial antigen, was prepared by sonicating leishmania major promastigotes used to induce immunity in balb/c mice against cutaneous leishmaniasis. correlation between the route of antigen injection and the efficacy of induced protection was examined. to enhance the effectiveness of the antigen, an immunostimulant drug, daraprim (pyrimethamine), was administered simult...