This article discusses the potential role of oxidative injury to the intestinal tract of horses and the therapeutic approaches that have been investigated to decrease cellular damage secondary to ischemia-reperfusion (IR) injury. Equine colic is a major concern for horse owners and veterinary practitioners. Strangulating and obstructive lesions of the small and large intestines commonly require...

I grew up in a medical family with a father and uncle as physicians, and two great grandfathers. In fact, I still have the saddlebags of my great grandfather who was a horse and buggy doctor in the valley of Virginia. So I never thought of anything but medicine. I attended Washington and Lee University, and my medical school acceptance was salvaged by Dr. Keith Shillington. He literally tied me...

BACKGROUND The optimal fluid strategy for the early treatment of trauma patients remains highly debated. Our objective was to determine the efficacy of an initial bolus of resuscitative fluids used in military and civilian settings on the physiologic response to uncontrolled hemorrhagic shock in a prospective, randomized, blinded animal study. METHODS Fifty anesthetized swine underwent centra...

Stain, S.C., Yellin, A.E., Donovan, A.J. and Brien, H.W. Pyogenic Liver Abscess. Archives of Surgery, 126: 991-996. Historically, open surgical drainage has been the treatment of choice for pyogenic liver abscess. The records of 54 patients with pyogenic liver abscess were reviewed to determine whether earlier diagnosis with current imaging tests and definitive treatment with antibiotics, aspir...

A 21-YEAR-OLD MALE PATIENT was admitted to the emergency department after a gunshot wound entering the right flank. The patient was in shock, with a blood pressure of 80/40 mmHg, 130 bpm heart rate, and a Glasgow Coma Scale of 10. We calculated an Injury Severity Score of 25 and Revised Trauma Score of 6,171. His breath sounds were normal. His initial base deficit was !12.4. No exit wound was v...

The treatment of the rare enteric nervous system (ENS) manifestations of paraneoplastic syndromes, which are most frequently associated with small cell lung cancer (SCLC), is poorly understood and described. Patients with neuroendocrine-derived tumors can develop B-cell reactivity towards the tumor with cross-reactivity for neurons located in the submucosal and myenteric ganglia of the ENS. The...

Ischemia Reperfusion injury is the tissue damage caused when blood supply returns to the tissue after a period of ischemia or lack of oxygen. In this study, the effect of pentoxyfylline on BCL-2 gene expression changes and cell injury in kidney of rat following Ischemia Reperfusion were evaluated. In this experimental study, 20 male wistar rats with average weight of 250-300 g were selected and...

PURPOSE Histological study of vascularization between a cecal pedicle flap and the testicle of Wistar rats. METHODS Fifty-three rats were studied. G1: submitted to celiotomy (a), mobilization of the right testicle (RT) to the abdomen (b), cecal flap suture to the RT (d) and cavity closure. G1: procedures a, b and d and fixation of RT into abdomen. G3: procedures a, b and d, exposition of RT t...

OBJECTIVE Feline gastrointestinal eosinophilic sclerosing fibroplasia (FGESF) is a recently described inflammatory disease of cats affecting stomach or intestines and draining regional lymph nodes. This study presents clinical and laboratory data on 13 newly described cases from Australia (11) and the UK (two). OBSERVATIONS The disease was most often observed in middle-aged cats (median 7 yea...