BACKGROUND The continued presence of biofilm may be one cause of the high risk of failure observed with irrigation and débridement with component retention in acute periprosthetic joint infection (PJI). There is a poor understanding of the role of biofilm antibiotic tolerance in PJI. QUESTIONS/PURPOSES (1) Do increasing doses of cefazolin result in decreased viable biofilm mass on arthroplast...

background: surgical site infection is known as a common complication after cardiac surgery, and cefazolin is the best prophylactic antibiotic to prevent this complication. the goal of this study was to evaluate the effect of continuous and intermittent cefazolin for the prevention of superficial surgical site infection following off-pump coronary artery bypass (opcab). methods: this prospectiv...

OBJECTIVE To compare intraosseous concentrations and inhibitory effects on the growth of Staphylococcus aureus following intravenous administration of 1 or 2 g of the prophylactic cefazolin between patients with decreased renal function vs. intact renal function undergoing total knee arthroplasty. PATIENTS AND METHODS Ten patients (13 knees) with primary knee osteoarthritis were divided into ...

BACKGROUND Alcohol extract from the root of Urena lobata L. (ULL) had broad spectrum antimicrobial activity. Studies in vitro have sho that ULL aqueous extract has antibacterial effect on S. aureusis, and the combination therapy of the ULL aqueous extract with cefazolin sodium showed additive effect. MATERIALS AND METHODS The mice underwent nasal inhalation with S. aureus, a subset of mice we...

We investigated the relationship between beta-lactamases of Bacteroides fragilis organisms and their resistance to cephalosporins. Timed killing curves were used to study the in vitro activity of three cephalosporins, cephalothin, cefazolin, and cefamandole, and a semisynthetic cephamycin, cefoxitin. Measurements of residual antibiotic concentrations in culture supernatants were made, and they ...

BACKGROUND The incidence of surgical site infection in bariatric patients is significant and the current recommendations for antibiotic prophylaxis are sometimes inadequate. Objective: The aim of this study was to analyze the effect of three prophylactic antibiotic regimens on the incidence of surgical site infection. METHODS A prospective, cross-sectional study was conducted between January ...

We prospectively compared once-daily administration of ceftriaxone with cefazolin given every 8 h for the treatment of skin and soft tissue infections. Thirty-one patients received cefazolin for a mean of 4.5 days, and 26 patients received ceftriaxone for a mean of 4.0 days. All patients had a satisfactory response. Adverse reactions were few and reversible. Ceftriaxone given as a single daily ...

purpose: to compare the efficacy of treatment with fortified cefazolin-gentamicin versus fortified vancomycin-ceftazidime eye drops for treatment of bacterial corneal ulcers. methods: a double-blind clinical trial was performed on 89 patients with bacterial corneal ulcers who were referred to feiz hospital, isfahan, iran from 2004 to 2005. patients were randomly assigned to two groups: one grou...

ASSAY CURVES, USING A DISK DIFFUSION METHOD FOR THE ANTIBIOTICS GENTAMICIN AND CEFAZOLIN, WERE PREPARED WITH: saline, saline plus 10% serum, and ascitic, synovial, cerebrospinal, and pleural fluids. The curves were compared with a standard curve prepared with pooled human serum. The pH, total protein, glucose, blood urea nitrogen, sodium, potassium, calcium, phosphorus, chloride, CO(2) content,...