نتایج جستجو برای: cd44 سیکل سل

تعداد نتایج: 14607  

Journal: :The Journal of Experimental Medicine 1995
J Lesley N English A Perschl J Gregoroff R Hyman

CD44 is a major cell surface receptor for the extracellular matrix glycosaminoglycan hyaluronan (HA). However, the ability of CD44 to bind ligand is strictly regulated. Three activation states of CD44 have been demonstrated: (a) inactive; (b) inducible (by certain CD44-specific mAb); and (c) constitutively active. Starting with two parental cell lines expressing CD44 in the inactive state, a pr...

Journal: :Stem cells translational medicine 2015
Yongmin Yan Xiangsheng Zuo Daoyan Wei

UNLABELLED The reception and integration of the plethora of signals a cell receives from its microenvironment determines the cell's fate. CD44 functions as a receptor for hyaluronan and many other extracellular matrix components, as well as a cofactor for growth factors and cytokines, and thus, CD44 is a signaling platform that integrates cellular microenvironmental cues with growth factor and ...

Journal: :Journal of immunology 2013
Vibuthi Singh Ulrike Erb Margot Zöller

A CD44 blockade drives leukemic cells into differentiation and apoptosis by dislodging from the osteogenic niche. Because anti-CD49d also supports hematopoietic stem cell mobilization, we sought to determine the therapeutic efficacy of a joint CD49d/CD44 blockade. To unravel the underlying mechanism, the CD49d(-) EL4 lymphoma was transfected with CD49d or point-mutated CD49d, prohibiting phosph...

Journal: :Infection and immunity 2005
Robert J McKallip Michael Fisher Ursula Gunthert Andras K Szakal Prakash S Nagarkatti Mitzi Nagarkatti

Exposure to bacterial superantigens such as staphylococcal enterotoxin B (SEB) leads to the induction of toxic shock syndrome which results in multiorgan failure, including liver damage. In the present study, we investigated the role of CD44 in SEB-induced liver injury. Injection of SEB into d-galactosamine-sensitized CD44 wild-type (WT) mice led to a significant increase in CD44 expression on ...

2013
MAO SUN WEI ZHOU YUN-YUN ZHANG DONG-LIN WANG XIAO-LING WU

CD44 has been confirmed as a cancer stem cell marker in a variety of human cancer cell lines and primary tumours, but whether this marker is applicable to gastric cancer (GC) remains unknown. The responses of CD44+ GC stem-like cells to chemoradiation and the roles they play in cancer invasion are not well understood. In the present study, cell sorting was applied to the poorly differentiated h...

Journal: :iranian journal of basic medical sciences 0
atena mansouri division of human genetics, immunology research center, avicenna research institute, mashhad university of medical sciences, mashhad, iran department of genetic, faculty of science, shahid chamran university of ahvaz, ahvaz, iran ali mohammad foroughmand department of genetic, faculty of science, shahid chamran university of ahvaz, ahvaz, iran mohammad reza abbaszadegan division of human genetics, immunology research center, avicenna research institute, mashhad university of medical sciences, mashhad, iran medical genetics research center, faculty of medicine, mashhad university of medical sciences, mashhad, iran bahram memar pathology department, imam reza hospital, faculty of medicine, mashhad university of medical sciences, mashhad, iran

objective(s):  cd44 is a member of the cell adhesion molecules family. naturally, cd44s, along with cd44v3 influence the cell motility, migration, and adhesion, while in tumor cells they lead to tumor invasion, progression, and metastasis. the purpose of this research is to evaluate the cd44s and cd44v3 expression in esophageal squamous cell carcinoma (escc) and to reveal their correlations wit...

Journal: :The Journal of Cell Biology 2000
Larry S. Sherman Tilat A. Rizvi Saikumar Karyala Nancy Ratner

We describe a key role for the CD44 transmembrane glycoprotein in Schwann cell-neuron interactions. CD44 proteins have been implicated in cell adhesion and in the presentation of growth factors to high affinity receptors. We observed high CD44 expression in early rat neonatal nerves at times when Schwann cells proliferate but low expression in adult nerves, where CD44 was found in some nonmyeli...

Journal: :FEBS Letters 2021

Sialic acid-binding immunoglobulin-like lectin-15 (Siglec-15) has been identified as a novel potential target for cancer immunotherapy. Here, we explored the role of Siglec-15 in human hepatoma cells. In this study, found that expression is substantially upregulated liver tissues comparison with nontumor tissues. Functionally, vitro experiments show promotes migration Furthermore, data demonstr...

Journal: :International journal of oncology 2012
Sang Hyuk Cho Yeon Sun Park Hun Jin Kim Chang Hyun Kim Sang Woo Lim Jung Wook Huh Jae Hyuk Lee Hyeong Rok Kim

The metastatic process involves the migration and invasion of cancer cells throughout the body to produce secondary tumors at distant sites. Through of epithelial-mesenchymal transition (EMT), cancer cells employ developmental processes to gain migratory and invasive properties. CD44 is the transmembrane adhesion receptor for Hyaluronan (HA) and p...

Journal: :Cancer research 2008
Jurrit Zeilstra Sander P J Joosten Maarten Dokter Eugène Verwiel Marcel Spaargaren Steven T Pals

Mutation of the genes encoding the WNT signaling components adenomatous polyposis coli or beta-catenin plays a critical role in the initiation of colorectal cancer. These mutations cause constitutively active beta-catenin/TCF-mediated transcription, driving the transformation of intestinal crypts to colorectal cancer precursor lesions, called dysplastic aberrant crypt foci. CD44 is a prominent ...

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