background: dendritic cells (dc) are a key regulator of the immune response, and interferon- beta (ifn-β) is considered an immunomodulatory molecule for dc. objective: the purpose of this study was to evaluate the ability of ifn-β treated dc to induce cytokine secretion by cd4+ t cells. methods: dendritic cells were generated from blood monocytes with granulocyte-monocyte colony-stimulating fac...

Background: Atherosclerosis is a multifactorial disorder with chronic inflammatory conditions in which immune cells play a significant role in its pathogenic process. Regulatory T cells (Treg), as a part of immune system, are involved in controlling autoimmune and inflammatory diseases. Quantitative and/or functional alteration of Tregs has been shown to play an atheroprotective role and may al...

The subpopulations of T-Iymphocytes were studied in children with visceral leishmaniasis in the active stage of disease prior to treatment (n=28) and in controls (n=15) using specific monoclonal antibodies (Behring OKT3, OKT4 and OKT8). The percentage of total peripheral blood T-Iymphocytes (CD3+ T-cells) in patients were within the same range as those of normal children (71.09± 1.07 vs68.8...

This review summarizes recent progress in understanding the pathogenesis of IgG4-related disease (IgG4-RD), with a focus on fibrosis. Several studies reported that CD4+ T cells cytotoxic activity promoted by secretion granzyme and perforin, (CD4+CTLs), disease-specific activated B cells, infiltrated inflamed tissues cooperated to induce tissue fibrosis autoimmune fibrotic diseases such as IgG4-...

newly  identified  t  helper  cell  22  (th22)  is  a  subset  of  cd4+t  cells  with  specific properties apart from other known cd4+ t cell subsets with distinguished gene expression and function. th22 cells are characterized by production of a distinct profile of effector cytokines, including interleukin (il)-22, il-13, and tumor necrosis factor-α (tnf-α). the levels of th22 and related cyto...

Background: Recurrent miscarriage (RM) affects 2-5% of pregnant women. Paternal lymphocyte immunotherapy is a common treatment for RM patients but the outcome has not been consistent. Therefore, combined therapy with other immunosuppressive drugs such as 1 a, 25-dihydroxy-vitamin-D3 (vitamin D3) may improve the outcome. Objectives: To investigate the effect of vitamin D3 on the balance of two...