Background and Aims: Crimean-Congo hemorrhagic fever (CCHF) is a zoonosis caused by a Nairovirus of the family Bunyaviridae. Infection is transmitted to humans mostly by Hyalomma ticks. This study was conducted to determine the rate of CCHFV infection in ticks in Qom province of Iran. Materials and Methods: In this study, Reverse transcription – polymerase chain reaction (RT-PCR) was used...

Crimean Congo hemorrhagic fever virus (CCHFV) is a deadly human pathogen that evades innate immune responses by efficiently interfering with antiviral signaling pathways mediated by NF-κB, IRF3, and IFNα/β. These pathways rely on protein ubiquitination for their activation, and one outcome is the modification of proteins with the ubiquitin (Ub)-like modifier interferon-stimulated gene (ISG)15. ...

The recent Middle East respiratory syndrome coronavirus (MERS-CoV), Ebola and Zika virus outbreaks exemplify the continued threat of (re-)emerging viruses to human health, and our inability to rapidly develop effective therapeutic countermeasures. Many viruses, including MERS-CoV and the Crimean-Congo hemorrhagic fever virus (CCHFV) encode deubiquitinating (DUB) enzymes that are critical for vi...

Viral hemorrhagic fevers (VHFs) are acute infections with high case fatality rates. Important VHF agents are Ebola and Marburg viruses (MBGV/EBOV), Lassa virus (LASV), Crimean-Congo hemorrhagic fever virus (CCHFV), Rift Valley fever virus (RVFV), dengue virus (DENV), and yellow fever virus (YFV). VHFs are clinically difficult to diagnose and to distinguish; a rapid and reliable laboratory diagn...

We report here the full-length sequences of 16 historical isolates of Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) obtained in Turkey, Namibia, and South Africa. The strains may be useful for future work to develop molecular diagnostics or viral evolution studies.

crimean-congo hemorrhagic fever is a tick-borne viral disease reported from more than 30 countries in africa, asia, south-east europe, and the middle east. the majority of human cases are workers in livestock industry, agriculture, slaughterhouses, and veterinary practice. the current mortality rate in endemic areas varies between 5 to 20 percent depending on the geographic location and medical...

Background: Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral disease of humans that most widespread in Africa, Asia, the Middle East and Southeast Europe. The has continued to be health problem Turkey other endemic countries recent years. CCHF virus does not cause clinical animal hosts but develops an antibody response transient viraemia. aim this study evaluate status infection ser...

Results: Th e overall prevalence of antibodies reactive with R. conorii was 36.81%. Th e prevalence of antibodies to R. conorii infection was higher in humans who showed CCHFV seropositivity than seronegativity, 52.32% and 25.82%, respectively (P = 0.001). A signifi cant diff erence in seroprevalence was found between groups who had a history of tick bite and who did not, 41.52% and 29.29%, res...

Crimean-Congo hemorrhagic fever (CCHF) is an emerging zoonotic disease in India and requires immediate detection of infection both for preventing further transmission and for controlling the infection. The present study describes development, optimization, and evaluation of a novel molecular beacon-based real-time RT-PCR assay for rapid, sensitive, and specific diagnosis of Crimean-Congo hemorr...