We show that the problem of finding an optimal bundle-pricing for a single additive buyer is #P-hard, even when the distributions have support size 2 for each item and the optimal solution is guaranteed to be a simple one: the seller picks a price for the grand bundle and a price for each individual item; the buyer can purchase either the grand bundle at the given price or any bundle of items a...

BACKGROUND Impaired endothelium-mediated vasodilatation (EMVD) in congestive cardiac failure (CCF) has been linked to decreased nitric oxide (NO) bioavailability because of its interaction with vascular superoxide (O2*-), derived predominantly from NAD(P)H-dependent oxidases. When uncoupled from essential cofactors, endothelial nitric oxide synthase (eNOS) produces O2*-. We studied the function...

We investigated whether the relative contribution of the baroreflex and central commands to the control of heart period differs between spontaneously hypertensive rats (SHR) and Wistar-Kyoto normotensive rats (WKY) during physiological behavior. Rats were instrumented with an arterial catheter and with electrodes for discriminating wakefulness, nonrapid eye movement sleep (NREMS), and rapid eye...

BACKGROUND Platelet depletion is a key feature of hemolytic uremic syndrome (HUS) caused by Shiga toxin-producing Escherichia coli (STEC) infection. The mechanism underlying STEC-induced platelet depletion, however, is not completely understood. METHODOLOGY/PRINCIPAL FINDINGS Here we demonstrated for the first time that platelet surface expression of CD47 was significantly decreased in C57BL6...

Traumatic carotid cavernous fistula (CCF) presents most commonly as a direct connection between the cavernous segment of internal carotid artery (ICA) and cavernous sinus (CS), and often accompanies basal skull fracture (BSF). The most frequently reported signs and symptoms are proptosis, chemosis, and bruit. Epistaxis is uncommon symptom of CCF. A 63-year-old man with a history of BSF due to b...

Ehlers-Danlos syndrome (EDS) is a rare inherited connective disease. Among several subgroups, type IV EDS is frequently associated with spontaneous catastrophic bleeding from a vascular fragility. We report on a case of carotid-cavernous fistula (CCF) in a patient with type IV EDS. A 46-year-old female presented with an ophthalmoplegia and chemosis in the right eye. Subsequently, seizure and ce...

Continuous cover forestry (CCF) is desirable for many reasons, but this silvicultural 5 approach does add to the complexity of predicting forest growth and timber yield. 6 Many well established techniques such as yield tables and age-based growth 7 models – techniques that are well-established and known to be useful and reliable – 8 are not applicable in the all-aged forests that develop with c...

Most work in mechanism design assumes that buyers are risk neutral; some considers risk aversion arising due to a non-linear utility for money. Yet behavioral studies have established that real agents exhibit risk attitudes which cannot be captured by any expected utility model. We initiate the study of revenue-optimal mechanisms under buyer behavioral models beyond expected utility theory. We ...

Abstract The objective of this study is to provide a numerical modeling approach for continuous carbon fiber (CCF)-reinforced fused filament fabricated composites. Although these materials have been extensively studied, an effective technique their mechanical performance does not exist. To fill technical gap, based on finite element analysis presented. material properties the Onyx matrix when v...

Background. A carotid-cavernous sinus fistula (CCF) is an abnormal communication between the internal carotid artery and/or external and cavernous sinus. There a paucity of information on ophthalmic outcomes endovascular treatment for CCF in Philippines.Objectives. This study aimed to describe clinical experience our institution order further ourunderstanding disease. described demographic prof...