BACKGROUND Hepatitis B virus-associated glomerulonephritis (HBV-GN) is one of the extrahepatic manifestations after HBV infection, which would cause great clinical harm to people. The present study was undertaken to investigate the HBV-GN genotypes and its clinical relevance in Chinese children. METHODS A total of 41 HBV-infected children diagnosed with HBV-GN were enrolled in the study. All ...

Background: Intrahepatic covalently closed circular DNA (cccDNA) plays a critical role in the life cycle of hepatitis B virus (HBV). Growing evidence suggests that microRNAs (miRNAs) may regulate cccDNA expression and contribute to natural history chronic (CHB). Objectives: This study aimed investigate potential miRNA-mRNA regulatory axes intrahepatic CHB-GZ patients identify new therapeutic ta...

Lucifora et al. (Research Articles, 14 March 2014, p. 1221) report that the hepatitis B virus (HBV) transcriptional template, a long-lived covalently closed circular DNA (cccDNA) molecule, is degraded noncytolytically by agents that up-regulate APOBEC3A and 3B. If these results can be independently confirmed, they would represent a critical first step toward development of a cure for the 400 mi...

Approximately 250 million people worldwide are chronically infected with the hepatitis B virus (HBV) and at increased risk of developing cirrhosis hepatocellular carcinoma. The HBV genome persists as covalently closed circular DNA (cccDNA), which serves template for all mRNA transcripts. Current nucleos(t)ide analogs used to treat do not directly target cccDNA thus cannot eradicate infection. H...