Purpose: The objective of this study was to evaluate the antitumor efficacy of trabectedin in clear cell carcinoma (CCC) of the ovary, which is regarded as an aggressive, chemoresistant, histologic subtype. Experimental Design:Using 6 human ovarian cancer cell lines (3 CCC and 3 serous adenocarcinomas), the antitumor effects of trabectedin were examined in vitro, and we compared its activity ac...

Preparata and Vuillemin proposed the cube-connected cycles (CCC) in 1981 16], and in the same paper, gave an asymptotically-optimal layout scheme for the CCC. We give a new layout scheme for the CCC which requires less than half of the area of the Preparata-Vuillemin layout. We also give a non-trivial lower bound on the layout area of the CCC. There is a constant factor of 2 between the new lay...

ÐPreparata and Vuillemin proposed the cube-connected cycles (CCC) and its compact layout in 1981 [17]. We give a new layout of the CCC which uses less than half the area of the Preparata-Vuillemin layout. We also give a lower bound on the layout area of the CCC. The area of the new layout deviates from this bound by a small constant factor. If we aunfoldo the cycles in the CCC, the resulting st...

PURPOSE The aim of this study was to describe a method for non-open-sky continuous curvilinear capsulorhexis (CCC) with chandelier retroillumination for penetrating keratoplasty triple procedure and report its effectiveness in decreasing intraoperative complications and enabling successful primary intraocular lens (IOL) insertion in patients with moderate or dense central corneal opacities. M...

Heart tissue destruction in chronic Chagas' disease cardiomyopathy (CCC) may be caused by autoimmune recognition of heart tissue by a mononuclear cell infiltrate decades after Trypanosoma cruzi infection. Indirect evidence suggests there is molecular mimicry between T. cruzi and heart tissue. In murine models of CCC, antibodies and CD4+ T cells recognize myosin, the major heart protein. We rece...

OBJECTIVES To investigate the relationship between neutrophil/lymphocyte ratio (NLR) and coronary collateral circulation (CCC) in patients with coronary chronic total occlusion. SUBJECTS AND METHODS Our study population consisted of 275 consecutive patients with chronic total occlusion. One hundred and thirty-eight patients with chronic total occlusion were included in the study. They were cl...

The Centers for Disease Prevention and Control's National Comprehensive Cancer Control (CCC) Program oversee CCC programs designed to develop and implement CCC plans via CCC coalitions, alliances, or consortia of program stakeholders. We reviewed 40 up-to-date plans for states and the District of Columbia in order to assess how capacity building and sustainability, two evidence-based practices ...

A clone of cells derived from a continuous line of cat cells (CCC) spontaneously produced an RNA C-type virus (CCC virus) which did not have the group-specific antigen of the standard strains of feline leukemia viruses but did have that of the RD-114 virus. Single-hit infection of a virus yielding CCC cell with only the feline leukemia virus pseudotype of murine sarcoma virus [MSV(FeLV)] result...

OBJECTIVE To analyse the morphological aspects of the extracellular matrix and microcirculation to clarify whether chronic Chagas' cardiopathy (CCC) is an accurate model to study the pathogenesis of idiopathic dilated cardiomyopathy (IDCM). DESIGN Thick histological myocardial sections were prepared to analyse collagen, and microcirculation was examined during confocal laser and light microsc...