Elevated oxidative stress has been characterized in numerous disorders including systemic hypertension, arterial stiffness, left ventricular hypertrophy (LVH) and heart failure. The peroxisome proliferator activated receptor gamma (PPARgamma) ameliorates oxidative stress and LVH. To test the hypothesis that PPARgamma decreased LVH and cardiac fibrosis in chronic pressure overload, in part, by i...

Cruzipain (Cz) is the major cysteine protease of the protozoan Trypanosoma cruzi, etiological agent of Chagas disease. A conformation-independent classifier capable of identifying Cz inhibitors was derived from a 163-compound dataset and later applied in a virtual screening campaign on the DrugBank database, which compiles FDA-approved and investigational drugs. 54 approved drugs were selected ...

The paper describes the process of building the Czech Digital Mathematics Library (DML-CZ) upon DSpace System. At first, the DML-CZ will be briefly introduced. Then we will describe DSpace system and its architecture together with Manakin—a system for building user interface above DSpace. The first technical part of the paper will be about mapping DML-CZ structure onto DSpace structures and abo...

In previous studies, enamel showed indications to occlude small cracks in-vivo and exhibited R-curve behaviors for bigger cracks ex-vivo. This study quantifies the crack tip's toughness (K(I0),K(III0)), the crack's closure stress and the cohesive zone size at the crack tip of enamel and investigates the toughening mechanisms near the crack tip down to the length scale of a single enamel crystal...

A fundamental question in developmental biology is how spatial patterns are self-organized from homogeneous structures. In 1952, Turing proposed the reaction-diffusion model in order to explain this issue. Experimental evidence of reaction-diffusion patterns in living organisms was first provided by the pigmentation pattern on the skin of fishes in 1995. However, whether or not this mechanism p...

Background Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen that is angiogenic in vitro and in vivo. It has been hypothesized that VEGE plays a role in myocardial collateral formation; however, the effects of VEGF on collateral flow to ischemic myocardium are unknown. Methods and Results We studied the effect of VEGF on collateral blood flow in dogs subjected to...

A daunting mine disaster took place in 13 May 2014 at Soma and 301 men lost their lives. Brief information about the Eynez coal mine and some of the inherent characteristics of the field in terms of their effects on mining are presented. This paper basically concentrates on the factors that played an important role in the occurrence of this disaster. Progress of mine fire, firefighting, and res...

Precise knowledge of spatial and temporal patterns of cell division, including number and orientation of divisions, and knowledge of cell expansion, is central to understanding morphogenesis. Our current knowledge of cell division patterns during plant and animal morphogenesis is largely deduced from analysis of clonal shapes and sizes. But such an analysis can reveal only the number, not the o...

The widespread use of pesticides in agriculture during the last several decades has contaminated soils and different Critical Zone (CZ) compartments, defined as area extended from top vegetation canopy to groundwater table, it integrates interactions atmosphere, lithosphere, biosphere, hydrosphere. However, long-term fate, storage, transfer dynamics persistent CZ a changing world remain poorly ...