peaked positive chronotropic responses, i.e., rapidly induced initial acceleration followed by slowly induced but long-lasting one. The initial positive response to caffeine was hardly suppressd by either adrenergic beta-blocking agents, H 56/28 (alprenolol) and propranolol, or tetrodotoxin. On the contrary, the secondary positive chronotropic response was effectively inhibited by either adrene...

cium was omitted from the medium, and markedly inhibited by the addition of cocaine. 3. Addition of reserpine or tyramine stimulated the release of catecholamine from the slices. The effect of reserpine was diminished in calcium free medium, but that of tyramine was not affected in calcium free medium. Cocaine had a weak inhibitory effect on the release of catecholamine caused by reserpine but ...

Keloid is a common skin hyperplastic condition and paradigm of fibrotic disease. The cell interactions that underlie fibroblast hyperfunction, increased extracellular matrix stiffness, keloid formation remain elusive, which restricts the design preventative or interventional strategies with targeted purposes. Here we performed single-cell transcriptomic analysis on human unexpectedly found new ...

1. Urinary excretion of dopa, catecholamines and their metabolites (vanillylmandelic acid, methoxycatecholamines, 3-methoxy-4-hydroxyphenylglycol and homovanillic acid) were studied in eighty patients with essential hypertension and in twenty-five healthy control subjects. 2. Increased urinary excretion of catecholamines, dopa and catecholamine metabolites was found in a proportion of cases. 3....

Pheochromocytomas are rare catecholamine secreting neuroendocrine tumors that can cause intracerebral hemorrhage sometimes and very rarely cardiomyopathy simulating hypertrophic obstructive cardiomyopathy. We report a case of combination these clinical complications occurring in patient with pheochromocytoma. This illustrates importance early recognition classic symptoms excess young patients h...

Introduction: Pheochromocytomas are catecholamine-producing neuroendocrine tumors that arise from the adrenal medulla. typically present with uncontrollable or paroxysmal hypertension can be accompanied by other common initial symptoms, including headache, diaphoresis, arrhythmia, and pallor. Given morbidity mortality associated undiagnosed pheochromocytomas, their potential for treatment, prim...