It is important to prevent nausea and vomiting to maintain both the quality of life of patients with cancer and the efficacy of chemotherapy. The aim of this study was to examine the efficacy of aprepitant for treatment of chemotherapy-induced nausea and vomiting (CINV) in Japanese patients with gastrointestinal cancer receiving highly or moderately emetogenic chemotherapy (HEC or MEC) regimens...

Stibnite (Sb2S3) semiconducting material was successfully synthesized by a rapid and facile microwave route using antimony chloride (SbCl3) and sodiumthiosulfate (Na2S2O3) dissolved in propylene glycol (PG) containing different hydroxyethyl cellulose (HEC) masses. The phase identification, morphology, and elemental composition of products were characterized by X-ray diffraction (XRD), transmiss...

Tracer-aided hydrological models are increasingly used to reveal fundamentals of runoff generation processes and water travel times in catchments. Modelling studies integrating stable water isotopes as tracers are mostly based in temperate and warm climates, leaving catchments with strong snow influences underrepresented in the literature. Such catchments are challenging, as the isotopic tracer...

A systematic study of the effects of polymer surface properties on the interaction with human endothelial cells (HEC) may lead to the development of small-diameter vascular grafts. HEC, suspended in culture medium containing 20% serum adhered and spread onto moderately wettable polymers such as TCPS (tissue culture polystyrene). Reduced or no adhesion of HEC was observed upon the hydrophobic po...

Retinoids exhibit chemotherapeutic and chemopreventive activities, possibly due to their ability to modulate cell growth, differentiation, and apoptosis. These effects are thought to be mediated by nuclear retinoic acid (RA) receptors (RARs) and retinoid X receptors, each of which includes three subtypes (a, b, and g) that act as transcription factors. To determine whether RARs play a role in m...

To deliver and retain viable repair cells in a surgically prepared cartilage lesion, we previously developed an adhesive in situ-gelling cell carrier by suspending cells in a solution of hydroxyethyl cellulose (HEC), which was then mixed with chitosan-glycerol phosphate to form a chitosan-GP/HEC gel. The purpose of this study was to elucidate the mechanism of gelation to maximally control gel t...

Retinoids exhibit chemotherapeutic and chemopreventive activities, possibly due to their ability to modulate cell growth, differentiation, and apoptosis. These effects are thought to be mediated by nuclear retinoic acid (RA) receptors (RARs) and retinoid X receptors, each of which includes three subtypes (a, b, and g) that act as transcription factors. To determine whether RARs play a role in m...

Within the Swedish Monitoring Programme for Agriculture, 27 small agricultural catchments were investigated for between 9 and 14 years (6 years for one catchment), starting in the late 1980s, to determine the impact of agricultural activities on discharge water. The catchments represent major variations in climate, soil types and farming in Sweden and hence long-term average load of total nitro...

BACKGROUND Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) coactivates multiple transcription factors and regulates several metabolic processes. In this study, we focused on the roles of PGC-1α in the apoptosis of endometrial cancer HEC-1A cells. MATERIALS AND METHODS PGC-1a expression in the HEC-1A cells was detected with real-time polymerase chain reaction and ...