A nonheme iron catalyst catalyzed stereoselective oxidation of alkanes with H2O2 with remarkable efficiency and exhibiting an unprecedented high incorporation of water into the oxidized products. The present results challenge the canonical description of oxygenases, the standard oxo-hydroxo tautomerism that applies to heme systems and serves as a precedent for alternative pathways for the oxida...

In studies of the oxidation of sulfhydryl compounds (I), selenite has been found to be an active catalyst. Considering the biological importance of sulfhydryl oxidations and the implication of sulfhydryl compounds in selenium poisoning (2-5), more information on selenite-catalyzed oxidations is desirable, This paper reports studies of the catalytic oxidation of GSH by selenite and its reaction ...

In the classical metabolic oxidation scheme, hydrophobic endogenous or xenobiotic compounds undergo phase I oxidation, generally catalyzed in the liver by cytochromes P450, followed by phase II conjugation reactions, in a way that allows much more polar metabolites to be expelled from the cell through active transport mechanisms. Cytochrome P450-mediated oxidation of steroid sulfate has been de...

A formal homogeneous gold-catalyzed A3-coupling, starting from benzyl alcohols, is reported for the straightforward synthesis of propargylamines. This first process where these highly valuable compounds have been synthesized, corresponding alcohols in a one-pot oxidation procedure using MnO2, followed by HAuCl4·3H2O catalyzed multicomponent reaction. The final products are obtained with very go...

Alkyl–alkyl cross-coupling is a powerful C–C bond-forming transformation typically catalyzed by late transition metals. Herein, we report mechanistic investigation into an early metal-catalyzed variant of this reaction. Through understanding, ideal Y catalyst was determined through tuning the metal in order to optimize oxidation potential, which governs rate-limiting step A wide substrate scope...

Under secondary metabolic conditions, the white-rot basidiomycete Phanerochaete chrysosporium degraded 2,7-dichlorodibenzo-p-dioxin (I). The pathway for the degradation of I was elucidated by the characterization of fungal metabolites and oxidation products generated by lignin peroxidase (LiP), manganese peroxidase (MnP), and crude intracellular cell-free extracts. The multistep pathway involve...

To investigate the involvement of reactive oxidant species (ROS), presumably arising from cytochrome P-450 (CYP)-catalyzed metabolism of schisandrin B (Sch B), in triggering glutathione antioxidant response, Sch B induced reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent and CYP-catalyzed reaction and associated ROS production were examined in rat heart microsomes. Sch B ana...

Hematin catalysis of unsaturated lipide oxidation is probably a primary reaction in many types of pathological unsaturated fat oxidation in viva (l-3) and in the spoilage of frozen meat products by oxidative fat rancidity (4). Some of the properties of hematin catalysis have been described (4-8), but knowledge of the reaction mechanism and the reaction products is relatively meager. The catalyt...