BACKGROUND The effect of the dose of carvedilol on cardiac sympathetic nerve activity (CSA) and mortality remain uncertain in patients with chronic heart failure (CHF). METHODS AND RESULTS To compare the dose of carvedilol and the transcardiac gradient of norepinephrine (NE), a biomarker of CSA, and prognosis in patients with CHF, hemodynamic parameters and plasma levels of NE, N-terminal bra...

acteristics. Furthermore, to avoid a basic misunderstanding of the objective of our study, one specific point needs to be emphasized. The study was not designed to address the question of whether one betablocker is more effective than another, but rather (as clearly stated in our article) to evaluate whether carvedilol may provide additional benefits in a select subgroup of patients with dilate...

In this study, various formulations of solidified carvedilol-loaded SMEDDS with high loading (up to 67% w/w) were produced the spray drying process using porous silica-based carriers. The yield was improved higher atomization gas flow rate during and prolonged mixing time dispersion liquid solid carriers prior process. Depending on choice carrier SMEDDS:carrier ratio in SMEDDS, different drug l...

OBJECTIVES This study investigates the effects of a change of beta-adrenergic blocking agent treatment from metoprolol to carvedilol and vice versa in patients with heart failure (HF). BACKGROUND Beta-blockers improve ventricular function and prolong survival in patients with HF. It has recently been suggested that carvedilol has more pronounced effects on left ventricular ejection fraction (...

BACKGROUND Currently, β-blockers are used most frequently for the purpose of heart rate (HR) control in patients with atrial fibrillation (AF) in worldwide. Carvedilol is one of common β-blockers and known to be effective for hypertension and heart failure. However, little can be found the information about the HR-lowering effect of carvedilol in patients with AF without heart failure. Therefor...

OBJECTIVES This study was performed to compare the long-term clinical efficacy of treatment with metoprolol versus carvedilol in patients with chronic heart failure. BACKGROUND Beta-adrenergic blockade is of proven value in chronic heart failure. Metoprolol, a selective beta-blocker, is widely used, but recent trials suggest carvedilol, a nonselective beta-blocker with alpha-1-receptor antago...

A capillary electrophoresis method was used for assay of some degradation products of carvedilol. The optimized parameters were as; running buffer 80 mM acetate dissolved in methanol/ethanol mixture (65:35% v/v), applied voltage of 19 kV, temperature is 20 ºC and the wavelength range of 200-350 nm. The results indicate that the proposed capillary electrophoresis method could effectively separat...

Dilatrend (carvedilol) is a nonselective beta and alpha blocker with antioxidation and antiprolipherative effects. These effects prevent mechanical damage of the endothelium of coronary arteries and have no negative influence on metabolic risk factors: lipid prophyl and insulin resistence. With beta-blockade, dilatrend (carvedilol) reduces the heart rate and blood pressure, with alpha-blockade ...

The present study was performed to investigate whether or not carvedilol (a beta-adrenoreceptor antagonist) potentiates the anticonvulsive activity of gabapentin against ICES (Increasing current electroshock) and PTZ (Pentylenetetrazole) induced seizures in mice. Further the effect of combination of both the drugs on spatial working memory and locomotor activity on rotarod was also evaluated. T...

OBJECTIVES This study examined the relative merits of digoxin, carvedilol, and their combination for the management of patients with atrial fibrillation (AF) and heart failure (HF). BACKGROUND In patients with AF and HF, both digoxin and beta-blockers reduce the ventricular rate, and both may improve symptoms, but only beta-blockers have been shown to improve prognosis. If combined therapy is...