Osthole is a bioactive coumarin derivative and has been reported to be able to enhance bone formation and improve fracture healing. However, the molecular mechanism of Osthole in bone fracture healing has not been fully defined. In this study we determined if Osthole enhances bone fracture healing through activation of BMP2 signaling in mice. We performed unilateral open transverse tibial fract...

An experimental study on physeal distraction was carried out in the distal femur of 45 two-month-old lambs for the purpose of identifying the basic mechanism of lengthening as well as assessing growth cartilage viability after lengthening. The animals were divided into three groups, each with three subgroups, according to the distraction rate employed (2 mm/day, 1 mm/day, 0.5 mm/day) and the ti...

The purpose of this study was to establish if the Bateman prosthesis functions as a bipolar device moving primarily at the inner metal-on-polyethylene bearing as originally proposed, or as a unipolar hemiarthroplasty moving at the outer metal-on-cartilage surface as has recently been suggested. One hundred hips were examined at one year follow-up; 78 were examined again at two to four years. Th...

BACKGROUND The aim of his study is to evaluate efficacy of elliptical head hemiarthroplasty in treatment of femoral neck and head fractures and related complications in young patients under 55 years of age. MATERIAL AND METHODS Uncemented elliptical head hemiarthroplasty was performed in 14 patients aged 28-55, mean age of 46,7 years, out of whom 12 diagnosed with a femoral neck fracture or r...

Infectious arthritis of which Erysipelas and Mycoplasma hyosynoviae are the most common causes. Septic laminitis bush foot due to bacterial infection. Physical lameness associated with deformed or damaged cartilage (variably termed osteochondrosis, osteochondritis, dyschondroplasia or degenerative joint disease (DJD)) and bony pathology leading to weakness and fracture (osteomalacia). There can...

Fracture healing involves a highly integrated sequence of events through which bone is restored to its preinjured condition. The events that occur during healing have been classically divided into four phases: inflammation, soft callus, hard callus, and remodeling (Figure 1). Initially, during the inflammatory stage, a hematoma forms in response to the trauma, and the inflammatory cells in the ...

Osteochondral lesions (OCD) of the talus are a common cause of chronic ankle pain and dysfunction, especially with history of injury and trauma to the ankle [1-3]. Lesions that do not respond to non-operative treatment may require surgical intervention arthroscopically or as an open procedure. Revision repair of osteochondral lesions historically has been performed as an open procedure with inc...

We reviewed nine patients at a mean period of 11 years (6 to 16) after curettage and cementing of a giant-cell tumour around the knee to determine if there were any long-term adverse effects on the cartilage. Plain radiography, MRI, delayed gadolinium-enhanced MRI of the cartilage and measurement of the serum level of cartilage oligomeric matrix protein were carried out. The functional outcome ...

Patients who have sustained a traumatic joint injury, such as a ligament rupture or cartilage fracture, are known to have an increased risk for the development of osteoarthritis (OA) in that joint. This has motivated the use of in vitro models of mechanical cartilage injury in order to identify processes that could lead to cartilage degradation. The overall aims of the work presented here has b...