The breast and ovarian cancer susceptibility gene-1 (BRCA1) located on chromosome 17q21 encodes a tumor suppressor gene that functions, in part, as a caretaker gene in preserving chromosomal stability. The observation that most BRCA1 mutant breast cancers are hormone receptor negative has led some to question whether hormonal factors contribute to the etiology of BRCA1-mutant breast cancers. Ne...

BACKGROUND The use of continuous peripheral nerve blocks at home (CPNBH) has improved patients' perioperative experience. In 30 months, 348 patients were sent home with interscalene CPNBH. METHODS With the Institutional Review Board (IRB) approval, all patients were surveyed for quality of analgesia and complications. The patients and their caretaker received verbal and written instructions, ...

BACKGROUND There is increasing interest in the social determinants of children's developmental outcomes in developing countries because of the links with schooling, behavioral, and employment outcomes. Yet, little is known about the impact of household and caretaker variables in influencing developmental outcomes in rural, developing country settings. AIM The study examined the relative impac...

This article presents lifetime and 12-month prevalence rates and comorbidity for posttraumatic stress disorder (PTSD) among a sample of 428 homeless and runaway adolescents. Data are from baseline interviews of a longitudinal diagnostic study of 428 (187 males; 241 females) homeless and runaway adolescents aged 16-19 years (mean age = 17.4 years, SD = 1.05). The data were collected by full-time...

Evidence for natural foamy virus (FV) infections in humans is still lacking. However, accidental infections of humans with simian FV have been demonstrated by serology and PCR, but all previous attempts to recover infectious virus in such cases have failed. Here we describe the isolation of a simian FV from peripheral blood mononuclear cells (PBMC) of a healthy animal caretaker, who acquired th...

Socialized wolves' relationship with humans is a much debated, but important question in light of dog domestication. Earlier findings reported no attachment to the caretaker at four months of age in a Strange Situation Test, while recently attachment to the caretaker was reported at a few weeks of age in a similar paradigm. To explore wolf-human relationship, we analysed behaviours of hand rear...

OBJECTIVE To quantify the degree of abuse or criminal behavior among young females presenting for reproductive health care services. METHODS An evaluation was conducted among Alaskan females age 10 through 15 years enrolled in Medicaid. Subjects were identified who had experienced reproductive health outcomes. The Medicaid file was linked to a Child Protective Services database and a Juvenile...