1287 cular risks of rosiglitazone led to a major change in FDA policy regarding the approval of all new diabetes drugs. From a cardiovascular perspective, rosiglitazone, saxagliptin, and alogliptin appear to be relatively safe. It is disappointing, however, that neither intensive glycemic control nor the use of specific diabetes medications is associated with any suggestion of cardiovascular be...

The effects of ergometrine 0.5 mg i.v. and of synthetic oxytocin 5 units i.v. on the alpha and the beta adrenoceptive blood vessels of the foreann have been studied by means of volume-pulse plethysmography in 40 gynaecological patients. Ergometrine constricted the alpha and the beta blood vessels. It is thought that the widespread vasoconstriction may precipitate post-partum hypertension or pul...

SAŽETAK: Hrvatska pripada skupini europskih zemalja s visokim kardiovaskularnim rizikom i rastućom prevalencijom šećerne bolesti tipa 2 (DMT2). Prema podatcima Nacionalnog registra osoba sa šećernom bolešću (CroDiab registar), u Hrvatskoj je 2014. godine bilo evidentirano ukupno 254 296 osoba oboljelih od dijabetesa starijih od 18 godina (7,9 %). DMT2 je, uz hipertenziju i hiperlipidemiju, jeda...

Ma Little is known about the benefits and risks of the long-term use of cardiovascular drugs. Evidence from randomized clinical trials (RCTs) rarely goes beyond a few years of follow-up, but patients are often given continuous treatment with multiple drugs well into old age. We focus on 4 commonly used cardiovascular drug classes: aspirin, statins, betablockers, and angiotensin-converting enzym...

cardiovascular morbidity and mortality at least four times higher compared to patients without diabetes. Moreover, it is well established nowadays that the cardiovascular risk of diabetic patients without a history of a prior myocardial infarction is similar to the risk of nondiabetic patients who have already had one. Hence, the reduction of cardiovascular risk in type 2 diabetic patients usin...

Ibn Sina (Avicenna), Persian famous and influential scholar of Islamic Golden Age lived between 981‐1037 A.D. He was a genius especially in medicine and philosophy. He wrote more than a hundred books and treatises dealing with philosophy, medicine, astronomy, geometry, philology, and art (1). His works are written mostly in Arabic, the lingua franca of the Islamic civilization. Although his med...

Digital innovation in cardiovascular medicine: a multi-stakeholder business Cardiovascular diseases affect 15 million people Europe, and digital solutions are now seen as very useful tools the search for new drugs medical devices. SimCardioTest is four-year project funded by European Commission that aims to develop credible computer modelling simulation approaches on cloud-based platform testin...

One of the main components of managing a patient with hypertension is deciding which drug to prescribe for first-line therapy. This decision should be made primarily on the basis of the best available evidence of the drug’s ability to prevent adverse health outcomes of the diseases. The objective of this review is to determine the relative effects of different antihypertensive drugs in reducing...