نتایج جستجو برای: cardiac progenitor cells

تعداد نتایج: 1638984  

Journal: :Science 2021

Forming the early heart The is first organ to form during development and critical for survival of embryo. precise molecular identities various cell types that make up these stages remain poorly defined. Tyser et al. used a combination transcriptomic, imaging, genetic lineage–labeling approaches profile identity locations cells involved in formation mouse embryonic heart. This approach allowed ...

Journal: :Cold Spring Harbor perspectives in medicine 2013
Thomas Brade Luna S Pane Alessandra Moretti Kenneth R Chien Karl-Ludwig Laugwitz

The mammalian heart is a highly specialized organ, comprised of many different cell types arising from distinct embryonic progenitor populations during cardiogenesis. Three precursor populations have been identified to contribute to different myocytic and nonmyocytic cell lineages of the heart: cardiogenic mesoderm cells (CMC), the proepicardium (PE), and cardiac neural crest cells (CNCCs). Thi...

Introduction: Nogo-A and Nogo receptor (NgR) are expressed in the subventricular zone (SVZ) stem cells. NgR plays critical inhibitory roles in axonal regeneration and remyelination. However, the role of NgR in SVZ niche behaviors in demyelination context is still uncertain. Here we investigated the effects of NgR inhibition on SVZ niche reaction in a local model of demyelination in adult mouse ...

Journal: :Journal of the American College of Cardiology 2018

2015
Michela Noseda Mutsuo Harada Sara McSweeney Thomas Leja Elisa Belian Daniel J. Stuckey Marta S. Abreu Paiva Josef Habib Iain Macaulay Adam J. de Smith Farah al-Beidh Robert Sampson R. Thomas Lumbers Pulivarthi Rao Sian E. Harding Alexandra I. F. Blakemore Sten Eirik Jacobsen Mauricio Barahona Michael D. Schneider

Cardiac progenitor/stem cells in adult hearts represent an attractive therapeutic target for heart regeneration, though (inter)-relationships among reported cells remain obscure. Using single-cell qRT-PCR and clonal analyses, here we define four subpopulations of cardiac progenitor/stem cells in adult mouse myocardium all sharing stem cell antigen-1 (Sca1), based on side population (SP) phenoty...

Journal: :Proceedings of the National Academy of Sciences 2008

Journal: :Proceedings of the National Academy of Sciences 2009

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