An unprecedented Pd-catalyzed hydrohalogenation of alkynyl halides for the regio- and stereoselective synthesis of (Z)-1,2-dihaloalkenes has been realized using [(allyl)PdCl](2) as the catalyst and cis,cis-1,5-cyclooctadiene as the ligand. The advantages of this protocol are well illustrated by the assembly of trisubstituted (Z)-enynes and multifunctional benzenes via iterative cross-coupling r...

Yasuhiro Okumura ([email protected]) Yutaka Yamamoto ([email protected]) Zhenhuan Zhang ([email protected]) Tatsuya Toyama ([email protected]) Teru Kawasoe ([email protected]) Mutsuko Ibusuki ([email protected]) Yumi Honda ([email protected]) Ken-ichi Iyama ([email protected]) Hiroko Yamashita ([email protected]) Hirotaka I...

Although carcinoma in situ has been accepted as a well-established concept and diagnostic category, for reasons unknown sebaceous carcinoma in situ has not been recognized yet in general pathology or dermatopathology. Such lesions have always been misinterpreted as either benign neoplasm or sebaceous carcinoma. In the present essay, we provide a convincing account supporting sebaceous carcinoma...

Ductal Echography (DE) is an anatomical method of breast investigation based upon the identification of mammary internal structures. By using the radial breast scanning DE is superior to other imagistic methods in breast investigation. In this paper the DE aspect of breast cancer will be presented.

purpose : to investigate the sensations experienced by chinese patients during refractive surgery including the laser in situ keratomileusis (lasik), epi-lasik, and sub-bowman keratomileusis (sbk) techniques. a prospective, randomized, and self-matched clinical study was conducted. methods : the participants included 44 men and 58 women aged 16 to 47 years old (mean 24.3±0.6 years) who underwen...

Background: Testicular Carcinoma in situ (CIS), also known as intratubular germ cell neoplasia (ITGCN), is a pre-invasive precursor of testicular germ cell tumours (TCGTs), i.e seminomas and non-seminomas -the commonest cancer type of male adolescents and young adults- which can be diagnosed using a surgical biopsy. Infertility is one of the condition known to predispose to TGCT, but based on s...

Background: Testicular cancer (TC) is usually diagnosed after manifestation of an overt tumour. Tumour formation is preceded by a pre-invasive and asymptomatic stage, carcinoma in situ (CIS) testis, except for very rare subtypes. The CIS cells are located within seminiferous tubules but can be exfoliated and detected in ejaculates with specific CIS markers. Materials and Methods: We have built ...