In this study, the effects of various hydrophilic (HPMC and Carbopol 971) and plastic (Ethylcellulose and Eudragit RL100) polymers on the release profile of diltiazem HCl from matrix tablets were evaluated in-vitro. For this purpose, tablets containing 60 mg of diltiazem HCl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. Tablets prep...

Latar belakang: Salep yang mengandung ekstrak ikan gabus dan madu kelulut terbukti mendukung penyembuhan luka. Sediaan salep pada penelitian sebelumnya menyatakan bahwa adanya ketidakstabilan sediaan. Hal ini ditandai dengan terjadinya pemisahan fase, ditambahkan carbopol untuk mencegah pemisahan. Tujuan berguna memperlihatkan sifat fisik ketika sebagai peningkat kosistensi sediaan terhadap sal...

In this work, the effect of cellulosic polymer and chemical structure of salicylic acid and its various esters on their release has been analysed. The release of different drugs in distinct types of vehicles, cetyl excipient, polyethylene glycol and Carbopol gel was also studied.  2001 Published by Elsevier Science B.V.

INTRODUCTION As a topical delivery system, a nanoscaled emulsion is considered a good carrier of several active ingredients that convey several side effects upon oral administration, such as nonsteroidal anti-inflammatory drugs (NSAIDs). OBJECTIVE We investigated the in vitro permeation properties and the in vivo pharmacodynamic activities of different nanoscaled emulsions containing ibuprofe...

Intranasal administration is an ideal alternative to the parenteral route for systemic drug delivery. Various conventional dosage forms have been employed for this purpose but they lack to provide the desired bioavailability of the drug due to poor residence time and faster clearance in the nasal cavity. Formulating multiparticulate system with mucoadhesive polymers may provide a significant in...

Purpose: To formulate topical gels containing various essential oils and evaluate their antibacterial activity against methicillin-resistant Staphylococcus Aureus (MRSA) skin infections. Methods: The four essential oils namely, lemon grass, rosemary, thyme and basil were steam-distilled and then evaluated for their antibacterial activity against MRSA. Lemon grass and thyme oils were chosen for ...

OBJECTIVES The objective of this study was to elucidate the safety and effectiveness of acemannan, a polysaccharide extracted from Aloe vera, in the treatment of oral aphthous ulceration. DESIGN A skin patch test was performed on 100 healthy subjects, and 0.5% acemannan in Carbopol® 934P NF (Lubrizol Corporation, USA) was applied to the oral mucosa of the lower lip of 50 healthy participants ...