A novel NHC–palladium(II) (NHC = N-heterocyclic carbene) complex and its immobilised version have been prepared and fully characterised. Optimisation studies led to good catalytic activities in Suzuki-Miyaura cross coupling and chloroarene dehalogenation reactions. Furthermore, the unexpected palladium-mediated transfer hydrogenation of a carbonyl compound is reported.

Chalcones are a class of α,β-unsaturated carbonyl compounds that form the central core for a variety of naturally occurring biologically active compounds. They exhibit tremendous potential to act as a pharmacological agent. Besides their various pharmacological activities, chalcones have been explored for different optical applications including second harmonic generation materials in non-linea...

Methods have recently been developed for the phosphine-catalyzed asymmetric γ-addition of nucleophiles to readily available allenoates and alkynoates to generate useful α,β-unsaturated carbonyl compounds that bear a stereogenic center in either the γ or the δ position (but not both) with high stereoselectivity. The utility of this approach would be enhanced considerably if the stereochemistry a...

A benchmark set of 28 medium-sized organic molecules is assembled that covers the most important classes of chromophores including polyenes and other unsaturated aliphatic compounds, aromatic hydrocarbons, heterocycles, carbonyl compounds, and nucleobases. Vertical excitation energies and one-electron properties are computed for the valence excited states of these molecules using both multiconf...

The pressure hydrogenation capabilities of the iridium pincer complexes IrH2Cl[((i)Pr2PC2H4)2NH] (1) and IrH3[((i)Pr2PC2H4)2NH] (2) are described and compared to related results obtained previously in transfer hydrogenation. Complex 1 was shown to act as a convenient air-stable entry point to the active catalyst 2, in the presence of base and hydrogen gas. The catalysts are active in a range of...

Herein, the synthesis, characterization and photocatalytic application of a novel hybrid polyoxometalate, which can absorb light in the visible region, are reported. This hybrid material was synthesized by attaching a monovacant polyoxometalate, (SiW11O39), through a (3-aminopropyl)triethoxysilane linker to the anthracene. The hybridization with anthracene drastically decreased the band gap of ...

The present work addresses the development of an eco-friendly and cost-efficient protocol for the oxidation of primary and secondary alcohols to the corresponding aldehydes and ketones by mechanical processing under air. Ball milling was shown to promote the quantitative conversion of a broad set of alcohols into carbonyl compounds with no trace of an over-oxidation to carboxylic acids. The mec...

3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4,5disubstituted pyrimidines and functionalized 4-aminopyridines. It also behaves like α-nitroformylacetic acid to give 5,6-disubstituted 3-nitro...

Because carbonyl groups are ubiquitous in organic chemistry, the ability to synthesize functionalized carbonyl compounds, particularly enantioselectively, is an important objective. We have developed a straightforward and versatile method for catalytic asymmetric carbon-carbon bond formation at the γ-position of carbonyl compounds, specifically, phosphine-catalyzed additions of malonate esters ...

When the hydrate reverts to starting materials, either of its two oxygen atoms must leave: one came from the water and one from the carbonyl group, so 50% of the time the oxygen atom that belonged to the carbonyl group will be lost. Usually, this is of no consequence, but it can be useful. For example, in 1968 some chemists studying the reactions that take place inside mass spectrometers needed...