BACKGROUND Cellulose acetate phthalate (CAP) in soluble form blocks coreceptor binding sites on the virus envelope glycoprotein gp120 and elicits gp41 six-helix bundle formation, processes involved in virus inactivation. CAP is not soluble at pH < 5.5, normal for microbicide target sites. Therefore, the interaction between insoluble micronized CAP and HIV-1 was studied. Carbomer 974P/BufferGel;...

Magnetohydrodynamic mixing was evaluated as an alternative to conventional high shear (HSM) in the preparation of carbomer hydrogels containing 1.22 wt% Carbopol® 980 NF. Neutralization dispersion (pH = 2.74) with triethanolamine (TEA) enabled adjust pH mixture and tune viscosity hydrogel. Using HSM, this approach limited 0.2 TEA 3.83) gel became too viscous recirculation flow dropped from 12 0...

An inactivated Equine herpes virus-1 vaccine was successfully improved using carbomer as adjuvant inducing high and long immunity in vaccinated mares comparison with the convention one adjuvanted Al-hydra gel saponin. Such purpose established by 0.5% to EHV-1. The applied quality control tests carried out on such revealed that it is free from foreign contaminants, safe pregnant mice potent indu...

Fusidic acid 1% and chloramphenicol 0.5% eye drops were in a randomized, single-blind manner given as a one-week treatment to out-patients with acute, purulent conjunctivitis. A clinical success was recorded in 84% (102/121) of patients receiving fusidic acid and in 81% (104/129) of patients receiving chloramphenicol. More patients (14%) receiving chloramphenicol complained of trivial side effe...

The aim. To identify the factors influencing in vitro release of dexpanthenol (DP) from solutions and semi-solid preparations.&#x0D; Materials methods. Dispersed systems containing 5.0 % DP were studied: that Newtonian liquids preparations (creams, gels ointment) with non-Newtonian flow behaviour. Rheological studies performed by rotational viscometry. In tests using vertical diffusion cells. c...

Oral transmucosal drug delivery is a non-invasive administration route for rapid therapeutic onset and greater bioavailability avoiding the first-pass metabolism. Mucoadhesive formulations are advantageous as they may retain at site. Proper equipment to assess mucoadhesive properties corresponding absorption fundamental development of novel systems. Here we developed new flow-through donor cham...

Objective- To evaluate the application of Carbomer 940 hydrogel on saving zone of stasis in skin burn wound. Design- Experimental study Animals- Twenty rats. Procedures- After shaving the backs, a ‘comb burn’ was contacted bilaterally on the dorsum of the rats 0.5 cm lateral and parallel to the midline by usin...