Porcine circovirus-associated disease is caused by porcine circovirus type 2 (PCV2) infection, which targets iliac artery endothelial cells (PIECs); it leads to severe immunopathologies and is associated with major economic losses in the porcine industry. Here, we report that in vitro PCV2 infection of PIECs causes cell injury, which affects DC function as well as adaptive immunity. Specificall...

background: to provide a point of reference to study the epidemiology and clin-ical expression of canine babesiosis in china. methods: a total of 30 dogs infected with canine babesiosis were evaluated by mean of clinical history, physical examination, hematological, restriction fragment length polymorphism of pcr products (pcr-rflp) and sequencing analysis. result: the most prevalent clinical a...

Abstract Introduction: Maxillary canines commonly have an ectopic eruption. This study aimed to assess the factors related to the ectopic maxillary permanent canines. Materials and Methods:This was a descriptive cross-sectional study of 1357 panoramic radiographs from patients 8 to 13 years old. The radiography was excluded if the patient had any developmental disease or if the panoramic im...

objectives : anterior maxilla, known as the esthetic zone, plays an important role in facial and smile esthetics. this study assessed the frequency of implant treatments in the esthetic zone of patients presenting to dental implant department of tehran university during 2002-2012. materials and methods: this descriptive study was conducted on dental records of patients receiving implant treatme...

Porcine circovirus 2 (PCV2) is currently considered an important etiologic agent of swine and its infection has potentially serious economic impact on the swine industry worldwide. This virus is frequently associated with postweaning multisystemic wasting syndrome (PMWS), and also with other clinical conditions such as porcine dermatitis and nephropathy syndrome (PDNS), late-term abortions, rep...

Porcilis PCV is a biotechnology derived inactivated immunological veterinary medicinal product intended to be used for the active immunisation of pigs against Porcine Circovirus Disease (PCVD). First recognised in 1991 in Canada, Porcine Circovirus Type 2 (PCV2) is considered to be associated with a number of disease syndromes which have been collectively named PCVD. In particular, infection by...

Porcine circovirus type 2 (PCV2) is the necessary agent for the occurrence of post-weaning multisystemic wasting syndrome (PMWS) in pigs. It has been suggested that PMWS-affected pigs are immunosuppressed and, therefore, more prone to develop co-infections. In this study, we elucidated that PCV2 downregulates in vitro the immune cell functions during recall antigen responses. We showed that PCV...

Since the earliest days of biological product manufacture, there have been a number of instances where laboratory studies provided evidence for the presence of adventitious agents in a marketed product. Lessons learned from such events can be used to strengthen regulatory preparedness for the future. We have therefore selected four instances where an adventitious agent, or a signal suggesting t...

• Porcine Circovirus 2 vaccines are vital in preventing large-scale losses pig farms. There is a need to develop low-cost against the prevalent PCV2d strains. A vaccine candidate has been expressed at very high levels E. coli . An effective single-step chromatography protocol gives yields of over 1 g/L culture. The purified product possesses virus neutralising activity cell based assays. circov...