نتایج جستجو برای: cancer biomarker
تعداد نتایج: 948270 فیلتر نتایج به سال:
Background and purpose: Single-nucleotide polymorphisms (SNPs) within miRNA genes may be related with risk of cancer. A main SNP in the pre-miR-27a (rs895819) with an A to G variation was earlier identified. In this study, we aimed to explore any association between SNP rs895819 in the miR-27a gene and breast cancer susceptibility. Materials and methods: This case-control study included 120 br...
This paper develops a new diagnosis model using urine biomarker proteins for early ovarian cancer diagnosis. The optimum marker combination that best classifies the benign tumor and cancer was determined from 15 biomarkers and the performance was evaluated. Samples consist of 121 patients with benign tumor, and 55 patients with ovarian cancer. 15 urine biomarkers showing specific reaction to ov...
Preoperative diagnostics of ovarian neoplasms rely on ultrasound imaging and the serum biomarkers CA125 and HE4. However, these markers may be elevated in non-neoplastic conditions and may fail to identify most non-serous epithelial cancer subtypes. The objective of this study was to identify histotype-specific serum biomarkers for mucinous ovarian cancer. The candidate genes with mucinous hist...
Introduction & Objective : Telomerase is a reverse transcriptase enzyme that is required in immortalized cancer cells. Early detection of telomerase activity in tumors particularly in bladder cancer is promising. The aim of this study was to compare specificity and sensitivity between cytology and telomerase activity in diagnosis of bladder cancer. Materials & Methods : This study was a case...
Background & Objective: Since colorectal cancer does not often have phenotypic symptoms in the early stages, the study of biomarkers for the diagnosis and prognosis of the tumor is very important. MicroRNAs are one of the most important biomarkers which attract the attention of many researchers due to a variety of reasons, including their non-invasive nature; these molecules are a group of non-...
objective(s):mirnas have been proposed to be key regulators of tumorigenesis, progression and metastasis. however, their effect and prognostic value in gastric cancer is still poorly known. materials and methods: gastric cancer cell lines were cultured. tissue samples obtained from 36 gastric cancer patients were used for quantitative real-time pcr (qrt-pcr) analysis. the tissue microarrays (tm...
Ovarian cancer is the most lethal gynaecologic cancer affecting women. The most widely used biomarker for ovarian cancer, CA125, lacks sensitivity and specificity. Here, we explored differences in glycosylation of CA125 between serum from patients with ovarian cancer and healthy controls. We found differences between CA125 N-glycans from patient sera compared to controls. These include increase...
This paper compares of biomarker combinations performance extracted from urine and serum samples for the early diagnosis of ovarian cancer. The sample consists of 22 benign and 10 cancer patients. The concentrations of 15 ovarian cancer-specific biomarkers were measured by antibody microbead-assisted multiplexed immunoassay technology. To determine the optimal combination that best distinguish ...
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