Breast cancer is the second main cause of death among women. The use of medicinal plants has been common in many countries since ancient times. The aim of this study was to evaluate the antioxidant and anti-proliferative potential of Achillea millefolium L. The antioxidant activity of the aqueous and hydroalcoholic extracts of Achillea millefolium L. leaf and flower was measured by DPPH and FRA...

Soybean isoflavone genistein has multiple anticancer properties and its pro-apoptotic and anti-proliferative effects have been studied in different cancer cells. However, the mechanisms of action of genistein and its molecular targets on human colon cells have not been fully elucidated. Therefore, caspase-3 and p38 mitogen-activated protein kinase (p38 MAPK) as the main therapeutic targets...

background: the organochlorine ddt has estrogenic activity but the mechanism underlying the estrogenic activity of this pesticide remains unclear. in the present investigation here, we studied the transcriptional effects of a synthetic organochlorine pesticide o,p’-ddt [1.1.1.-trichloro-2-(o-chlorophenyl)-2-p-chloriphenyl ethane] and its metabolite p,p'-dde (2-2-bis(4/chlorophenyl)-1-1-dic...

Esophageal cancer (EC) is the sixth main cause of cancer death worldwide. Important genes associated with esophageal cancer include FOXO3, AKT, and GSK3β. Excessive FOXO3 expression inhibits the proliferation of cancer cells. The expression of AKT is involved in controlling cell growth in tumors. GSK3β activity is higher in cancer tissues. Given the effective role of cancer stem cells (CSCs) in...

there is a continuing need to identify new agents that are active in ovarian cancer. etoposide is a derivative of the plant alkaloid epipodophyllotoxin. the availability of etoposide in oral preparation allows prolonged administration by the oral route. in this study, activity and toxicity of etoposide in women with recurrent ovarian cancer are described from a case series of women with recurre...

there are increasing data on novel tumor markers such as gelatinase a, which play a key role in tissue invasion and metastasis. since prostate cancer is one of the common malignancies, we designed a simple and applicable indi¬rect hemagglutination (iha) test for determination of total gelatinase a in se¬rum samples. in this study, we have analyzed the circulating form of gelatinase a (mmp-2) in...

objective(s): regarding the presence of many active biological constituents in avicennia marina, the present investigation was carried out to study cytotoxic activity of crude methanol leave extract and column chromatographic fractions of a. marina against mda-mb 231 cell line (human breast cancer cell) and hek (human embryonic kidney cell) line .   materials and methods: the anticancer activit...

aim : this study used the olga system to characterize the histology pattern of gastritis in dyspeptic outpatients with a mean age of 45 years from regions with different gastric cancer risks.   background : several classification systems have been purposed for understanding the status of the gastric mucosa.  currently, the sydney system is the most widely employed. nevertheless, the applicabili...

introduction: insertion or deletion of a guanine in -1607 at promoter region of matrix metalloproteinase-1 enzyme creates two allelic types for this gene in the population: 2g and 1g, respectively. 2g allele contains an extra binding site for ets transcription factors that this may increase the level of gene expression. therefore, aim of this study was investigation of the single guanine insert...

abstract objective: cancer is the second cause of death worldwide, among them liver cancer is the fifth most important malignancy. the aim of this study was to investigate chemopreventive activity of berberis vulgaris fruit extract in  hepatocarcinogenesis  sprague dawley rats. materials and methods: fourty-four sprague dawley rats (6-8 weeks old, 150-250g) were divided into normal and cancerou...