The crack epidemic, now a decade old, disabused neurologists of the idea that cocaine was a relatively safe drug. Acute neurologic complications of cocaine intoxication such as headaches, delirium, seizures, and strokes have now been amply delineated. Less clear is whether long-term cocaine use, uncomplicated by acute problems, can lead to structural or functional changes in the human brain. Br...

Potassium channels constitute the most diverse and widespread class of ion channels known. K channels have been found in all cells which display action potentials mediated by sodium or calcium ions. The different types of K channels are very often present in the same cells which shows, that their diversity is not associated with the cell type (for review see Latorre and Miller 1983; Rudy 1988)....

Lipcznska-Kochany et al. Charge-transfer complexation with a new class of electron acceptors made of a tryptycenequinone unit. Chemistry Letters (1982), (7), pp 1075-8 (abstract).* P. Bartlett et al., Triptycene (9,l&o-Benzenoanthracene), J. Am. Chem. SOC. 64:2649-53, 1942. P. Bedworth et al., The Synthesis of a symmetrically substituted a-octa(isopentoxy)anthralocyanine, J. Chem. SOC. Chem. Co...

There is now a widespread acceptance that persons with severe mental illness are at increased risk to develop substance use disorders (alcohol and drug abuse/dependence). Reviews of the prevalence of substance use disorders in clients with schizophrenia (Mueser et al. 1990), bipolar disorder (Goodwin and Jamison 1990), and the young, chronically mentally ill (Safer 1987) indicate a wide range o...

Bovine aortic endothelial cell (BAEC) attachments to laminin, fibronectin, and fibrinogen are inhibited by soluble arginine-glycine-aspartate (RGD)-containing peptides, and YGRGDSP activity is responsive to titration of either soluble peptide or matrix protein. To assess the presence of RGD-dependent receptors, immunoprecipitation and immunoblotting studies were conducted and demonstrated integ...

among different models for runoff estimation in watershed management, the soil conservation services-curve number (scs-cn) method along with its modifications have been widely applied to ungauged watersheds because of quickly and more accurate estimation of surface runoff. this approach has been widely accepted by hydrologists, water resources planners, foresters, and engineers, as well. theref...

In this work we present an analytical derivation of the excess current in Josephson microbridges, following the Octavio-Blonder-Tinkham-Klapwijk (OBTK) model. We can confirm previously found numerical results, including the prediction of negative excess current for low transparencies, which might possibly shed new light on questions concerning the validity of the OBTK approach. Introduction The...

firing patterns, e.g. by producing stochastic drift in grid attractor networks. Recently, Hardcastle et al. (Neuron, 2015) proposed that border cells may provide one mechanism for correcting such drift. We construct a model in which experience-dependent Hebbian plasticity during exploration allows border cells to self-organize their responses, while also learning connectivity to grid cells whic...

Stress fractures of the third metacarpal bone (McIII) are a common cause of lameness in Thoroughbred racehorses. The most commonly described location is the mid-dorsolateral cortex (Copelan 1979; Richardson 1984, 1999; Stashak 1987; Stover et al. 1988; Cervantes et al. 1992; Pilsworth and Shepherd 1997; Stover 1998; Sullins 1998), but they also occur distally and proximally in the dorsal cortex...

Psychological and somatic factors contribute and interact across the spectrum of health and illness. Their relative influence varies from disorder to disorder and from case to case, and specific instances of disorder might in theory be plotted along a continuum to represent different weightings of psychological and somatic causation (Lipowski, 1986; Oken, 1987). We can criticize such a model fo...