The article provides insight into the historical phenomenon of performed „radio broadcasts” conducted by female prisoners Nazi concentration camp at Majdanek, Poland. Every day over a period few months, women played role radio announcers and recreated from memory communication formulas Polish Radio broadcasts. associated pre-war with strong message cultural heritage humanist values. re-enactmen...

In addition to xenobiotics and several other endogenous metabolites, multidrug-resistance proteins (MRPs) extrude the second-messenger cAMP from various cells. Pharmacological and/or genetic inactivation of MRPs has been shown to augment intracellular cAMP signaling, an effect assumed to be a direct consequence of the blockade of cAMP extrusion. Here we provide evidence that the augmented intra...

The two exocyclic oxygen atoms at phosphorus of cAMP have been replaced by a sulfur atom or by a dimethylamino group. These substitutions introduce chirality at the phosphorus atom; therefore, two diastereoisomers are known for each derivative: (SP)-cAMPS, (RP)-cAMPS, (SP)-cAMPN(CH3)2, and RP-cAMPN(CH3)2. We have investigated the agonistic and antagonistic activities of these compounds in four ...

Background: Autophagy (self-feeding) assists survival of starving cells by partial self-digestion, while dormancy as cysts, spores or seeds enables long-term survival. Starving Dictyostelium amoebas construct multicellular fruiting bodies with and stalk cells, many Dictyostelia still able to encyst individually like their single-celled ancest...

cAMP-activated Na+ current (INa,cAMP) was studied in voltage-clamped neurons of the seaslug Pleurobranchaea californica. The current response to injected cAMP varied in both time course and amplitude as the tip of an intracellular injection electrode was moved from the periphery to the center of the neuron soma. The latency from injection to peak response was dependent on the amount of cAMP inj...

the effect of theophylline on colony stimulating factor production by the lung tissue was investigated. addition of various concentrations of theophylline to the lung conditioned medium enhanced csf production at 10 µg/ml and at higher concentrations showed an inhibitory effect. determination of the phosphate content of the medium showed a decrease at 1-3 hours of incubation. addition of amp to...

cAMP has previously been shown to promote cell survival in a variety of cell types, but the downstream signaling pathway(s) of this antiapoptotic effect is unclear. Thus the role of cAMP signaling through PKA and cAMP-regulated guanine nucleotide exchange factors (cAMP-GEFs) in cAMP's antiapoptotic action was investigated in the present study. cAMP's protective effect against bile acid-, Fas li...

The climatic and environmental impact of exclusively volcanic CO2 emissions is assessed during the main effusive phase Central Atlantic Magmatic Province (CAMP), which synchronous with end-Triassic mass extinction. CAMP volcanism occurred in brief intense eruptive pulses each producing extensive basaltic lava flows. Here, injections into surface system are modelled using a biogeochemical box mo...

The 3',5'-cAMP-adenosine pathway (3',5'-cAMP→5'-AMP→adenosine) and the 2',3'-cAMP-adenosine pathway (2',3'-cAMP→2'-AMP/3'-AMP→adenosine) are active in the brain. Oligodendrocytes participate in the brain 2',3'-cAMP-adenosine pathway via their robust expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase; converts 2',3'-cAMP to 2'-AMP). Because Schwann cells also express CNPase, it i...

the aim of the present study was to examine the impact of jihadi camps on the identity formationof teenagers in iran. seventy-six campers participated in the study and were randomly divided into control(n = 42) and experimental groups (n =34). the control group does not follow the camp’s regular program whilethe experimental group attended to the camp’s regular program. all participants complet...