INTRODUCTION In clinical situations, vascular calcification tends to progress and is difficult to completely arrest or reverse. Calciphylaxis, a severe complication of end-stage renal disease, is a specific form of vascular calcification. Control studies have provided evidence that monotherapy with sodium thiosulfate or cinacalcet delays the progression of vascular calcification. Successful tre...

Introduction: Non­uremic calciphylaxis, a rare disorder with high mortality, is associated with severe calcifications of the media of arterioles which cause vascular occlusion and tissue necrosis. Case Report: A non­uremic calciphylaxis of the lower limb, possibly caused by coumarin therapy for atrial fibrillation. Treatment consisting of coumarin avoidance, vitamin K supplementation and thrice...

INTRODUCTION Calciphylaxis is a rare but dreadful complication of chronic kidney disease. It is characterized by nodular subcutaneous calcification and painful tissue necrosis which often results in ulceration and secondary infection, leading to a high rate of mortality. Pathogenesis of this disease is not well understood and there are very few, poorly studied treatment options for this disease...

Olaoye OA, Koratala A. BMJ Case Rep 2017. doi:10.1136/bcr-2017-222674 Description The prevalence of vascular calcification in patients with advanced chronic kidney disease (CKD) is very high. It is thought that calciphylaxis and vascular calcification are a continuum of extraskeletal osteogenesis and the clinical manifestations depend on the location of the affected artery. 3 Calciphylaxis is a...

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BACKGROUND Calciphylaxis (calcific uremic arteriolopathy) is rare and its pathogenesis is not fully understood. Indeed, Calciphylaxis presents a challenge through the course of its management which involve different specialities but unfortunately this disease so far has a poor prognosis. We herein present, in this case report, a multidisciplinary approach involving plastic surgeons with special...

BACKGROUND Calciphylaxis is a rare, yet life-threatening disease mainly occurring in dialysis patients. Traditional options of treatment remain unsatisfactory. METHODS Here we present a novel, combined approach, treating calciphylaxis with IV sodium thiosulfate, cinacalcet and sevelamer. In a case series five hemodialysis patients, have been successfully treated with this regimen. Treatment a...