Sự bùng nổ của công nghệ kỹ thuật số đã làm thay đổi hoạt động nhiều loại hình kinh doanh và ngành nghiệp khác nhau. Dịch vụ kiểm toán, đảm nhiệm việc đánh giá sự tuân thủ luật pháp, chính sách, chế độ tài – kế toán hiệu quả các tổ chức, cũng phải thực hiện nghề ngày càng phức tạp. Trong bối cảnh đó, có hỗ trợ máy tính (CAAT) cung cấp cho viên lợi thế để một cách quả. Mục đích nghiên cứu này là...

The catabolism of chlorinated s-triazines, e.g., herbicides, is incompletely understood. The first demonstration of their quantitative microbial degradation is the fungal dealkylation of simazine (CEET [for meaning of abbreviations throughout, see Table 1, footnote a]) to two major products, deethylsimazine (CEAT; two-thirds of total) and an unidentified s-triazine (one-third of total) (11, 12)...

Transcription factors of the basic Helix-Loop-Helix (bHLH) protein family play key roles in several developmental processes. Mist1 belongs to this group of proteins and shares several properties with the other family members. For example, Mist1 is capable of dimerization with the ubiquitously expressed E2A bHLH proteins and exhibits a strong DNA-binding activity to the core E-box sequence. Usin...

BACKGROUND Alpha1,3-galactosyltransferase (alpha1,3GT) is an enzyme that produces carbohydrate chains termed alphaGal epitopes found in most mammals, although some species of higher primates, including human, are notable exceptions. The evolutionary origin of the lost alpha1,3GT enzyme activity is not yet known, although it has been suggested that the promoter activity of this gene in the ances...

In mammals, glutaminase (GA) is expressed in most tissues, but the regulation of organ-specific expression is largely unknown. Therefore, as an essential step towards studying the regulation of GA expression, the human liver-type GA (hLGA) gene has been characterized. LGA genomic sequences were isolated using the genome walking technique. Analysis and comparison of these sequences with two LGA ...

Food for Thought ... Read-Across Approaches – Misconceptions, Promises and Challenges Ahead Grace Patlewicz , Nicholas Ball , Richard A. Becker , Ewan D. Booth , Mark T. D. Cronin , Dinant Kroese , David Steup , Ben van Ravenzwaay 8 and Thomas Hartung 9 1 DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, DE, USA; 2 Toxicology & Environmental Research and Consulting (T...

Structural analysis of the Ets2 promoter has revealed the absence of TATA and CAAT boxes, thus allowing transcription initiation from multiple start sites (Papas et al., 1990a). The first Intron of Ets2 also contains transcriptional initiation sequences, facilitating transcription. These sequences may compensate for the absence of TATA and CAAT sites within the promoter (Begue et al., 1997). Th...

169 t4 Report* Evidence for the Detection of Non-Endotoxin Pyrogens by the Whole Blood Monocyte Activation Test1 Nina Hasiwa 1,2, Mardas Daneshian 1, Peter Bruegger 4, Stefan Fennrich 5, Astrid Hochadel 2, Sebastian Hoffmann 6, Felix E. Rivera-Mariani 3, Christoph Rockel 7, Stefanie Schindler 8, Ingo Spreitzer 9, Sandra Stoppelkamp 5, Kranthi Vysyaraju 3, and Thomas Hartung 1,3 CAAt-europe, Uni...